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Phenylalanine Hydroxylation Cofactor in Phenylketonuria

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Journal Science
Specialty Science
Date 1958 Dec 12
PMID 13615302
Citations 20
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Abstract

The enzymatic conversion of phenylalanine to tyrosine had previously been shown to require a nonprotein cofactor. It has now been demonstrated by direct assay that the cofactor is present in phenylketonuric liver samples. The lack of a functional phenylalanine hydroxylating system in phenylketonuria is not due to the absence of the cofactor.

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