The Influence of Platelet Aggregation Inhibitors on Metastasis Formation in Mice (3LL)

Overview

Journal Z Krebsforsch Klin Onkol Cancer Res Clin Oncol

Specialty Oncology

Date 1976 Aug 30

PMID 136099

Citations 18

Authors

P Hilgard

H Heller

C G SCHMIDT

Affiliations

Soon will be listed here.

Abstract

Platelets were suggested to play a specific role in the haematogenous spread of experimental tumours. To test this hypothesis mice were treated with various inhibitors or platelet function (acetyl-salicylic acid, RA 233, bencyclan-, cyproheptadine). The effect of treatment on the development of lung colonies after i.v. tumour cell injection as well as on the formation of spontaneous metastases from the solid Lewis-lung carcinoma was evaluated. A significant increase of lung colonies after pretreatment with the platelet aggregation inhibitors was found. The effect of long term treatment on spontaneous metastasis formation gave equivocal results. The present investigations do not support the importance of the integrity of platelet function as a prerequisite for metastasis formation.

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References

MOSCHOS C, Lahiri K, Lyons M, WEISSE A, OLDEWURTEL H, Regan T . Relation of microcirculatory thrombosis to thrombus in the proximal coronary artery: effect of aspirin, dipyridamole, and thrombolysis. Am Heart J. 1973; 86(1):61-8. View

WOOD Jr S, Hilgard P . Aspirin and tumour metastasis. Lancet. 1972; 2(7792):1416-7. DOI: 10.1016/s0140-6736(72)92982-0. View

Atherton A, BUSFIELD D, Hellman K . The effects of an antimetastatic agent, (plus or minus)-1,2-bis(3,5-dioxopiperazin-1-yl)propane (ICRF 159), on platelet behavior. Cancer Res. 1975; 35(4):953-7. View

Hilgard P . The role of blood platelets in experimental metastases. Br J Cancer. 1973; 28(5):429-35. PMC: 2008922. DOI: 10.1038/bjc.1973.168. View

Gasic G, Gasic T, Stewart C . Antimetastatic effects associated with platelet reduction. Proc Natl Acad Sci U S A. 1968; 61(1):46-52. PMC: 285903. DOI: 10.1073/pnas.61.1.46. View

Sindelar W, Tralka T, KETCHAM A . Electron microscopic observations on formation of pulmonary metastases. J Surg Res. 1975; 18(2):137-61. DOI: 10.1016/0022-4804(75)90010-4. View

Lindsay R, Ferguson D, Prentice C, Burton J, McNicol G . Reduction of thrombus formation on dialyser membranes by aspirin and RA 233. Lancet. 1972; 2(7790):1287-90. DOI: 10.1016/s0140-6736(72)92656-6. View

Hilgard P, Gordon-Smith E . Microangiopathic haemolytic anaemia and experimental tumour-cell emboli. Br J Haematol. 1974; 26(4):651-9. DOI: 10.1111/j.1365-2141.1974.tb00508.x. View

Martin M, Schafer G, Martin U, Juraschek H, Knull W . The inhibition of thrombocyte adhesion by bencyclane: experimental and clinical results. Thromb Res. 1974; 4(6):741-52. DOI: 10.1016/0049-3848(74)90018-8. View

10.

Gasic G, Gasic T, Galanti N, Johnson T, Murphy S . Platelet-tumor-cell interactions in mice. The role of platelets in the spread of malignant disease. Int J Cancer. 1973; 11(3):704-18. DOI: 10.1002/ijc.2910110322. View

11.

ZUCKER M, Peterson J . Inhibition of adenosine diphosphate-induced secondary aggregation and other platelet functions by acetylsalicylic acid ingestion. Proc Soc Exp Biol Med. 1968; 127(2):547-51. DOI: 10.3181/00379727-127-32737. View

12.

Wexler H . Accurate identification of experimental pulmonary metastases. J Natl Cancer Inst. 1966; 36(4):641-5. DOI: 10.1093/jnci/36.4.641. View

13.

Hagmar B . Experimental tumour metastases and blood coagulability. Acta Pathol Microbiol Scand Suppl. 1970; 211:Suppl 211:5+. View

14.

BRECHER G, CRONKITE E . Morphology and enumeration of human blood platelets. J Appl Physiol. 1950; 3(6):365-77. DOI: 10.1152/jappl.1950.3.6.365. View

15.

Mustard J, Packham M . Factors influencing platelet function: adhesion, release, and aggregation. Pharmacol Rev. 1970; 22(2):97-187. View

16.

Kovacs I, CSALAY L, Csakvary G . Antithrombotic and fibrinolytic effect of bencyclane. Arzneimittelforschung. 1971; 21(10):1553-6. View

17.

WOOD Jr S . Experimental studies on the spread of cancer, with special reference to fibrinolytic agents and anticoagulants. J Med. 1974; 5(1):7-22. View

18.

GASTPAR H . [Metastasis and blood coagulation]. Thromb Diath Haemorrh Suppl. 1968; 28:119-36; discussion 143-68. View