Memory and Naive CD4+ Lymphocytes in Multiple Sclerosis

Overview

Journal J Neurol

Specialty Neurology

Date 1992 Oct 1

PMID 1360022

Citations 6

Authors

A M Porrini

D Gambi

G Malatesta

Affiliations

Soon will be listed here.

Abstract

Helper-inducer (CD29+CD4+) and suppressor-inducer (CD45RACD4+) T-cells have been recently renamed as memory and naive T-cells, respectively. We measured cells expressing these phenotypes in peripheral blood of 46 definite multiple sclerosis (MS) patients [32 relapsing-remitting (RR-MS), 14 secondary progressive (P-MS)] and controls. CD25+ (interleukin-2-receptor-positive) cells were also evaluated in the same groups of patients. RR-MS patients showed increased levels of CD29+CD4+ and CD25+ cells compared with controls. This finding was more evident in RR-MS patients during the attack than during the stable phase of the disease. In P-MS patients we found a reduction of CD45+CD4+ cells compared with either RR-MS patients or control subjects. Our results show that RR-MS and P-MS are characterized by two different T-cell subpopulations. This finding supports the hypothesis that during the evolution from RR-MS and P-MS changes occur in the immunological status of the patients.

Citing Articles

Differences in systemic and central nervous system cellular immunity relevant to relapsing-remitting multiple sclerosis.

Matsui M, Araya S, Wang H, Matsushima K, Saida T J Neurol. 2005; 252(8):908-15.

PMID: 15772738 DOI: 10.1007/s00415-005-0778-z.

Expression of CCR2, CCR5, and CXCR3 by CD4+ T cells is stable during a 2-year longitudinal study but varies widely between individuals.

Kivisakk P, Trebst C, Lee J, Tucky B, Rudick R, Campbell J J Neurovirol. 2003; 9(3):291-9.

PMID: 12775413 DOI: 10.1080/13550280390201001.

Production of T-helper cell subsets and cytokines by lymphocytes from patients with chronic mucocutaneous candidiasis.

Kobrynski L, Tanimune L, Kilpatrick L, Campbell D, Douglas S Clin Diagn Lab Immunol. 1996; 3(6):740-5.

PMID: 8914768 PMC: 170440. DOI: 10.1128/cdli.3.6.740-745.1996.

CD4 subsets (CD45RA/RO) exhibit differences in proliferative responses, IL-2 and gamma-interferon production during intravenous methylprednisolone treatment of multiple sclerosis.

Crockard A, Treacy M, Droogan A, Hawkins S J Neurol. 1996; 243(6):475-81.

PMID: 8803822 DOI: 10.1007/BF00900503.

Alterations in peripheral blood mononuclear cell cytokine production in response to phytohemagglutinin in multiple sclerosis patients.

Crucian B, Dunne P, Friedman H, Ragsdale R, Pross S, Widen R Clin Diagn Lab Immunol. 1995; 2(6):766-9.

PMID: 8574845 PMC: 170236. DOI: 10.1128/cdli.2.6.766-769.1995.

References

Schumacher G, BEEBE G, KIBLER R, Kurland L, Kurtzke J, McDowell F . PROBLEMS OF EXPERIMENTAL TRIALS OF THERAPY IN MULTIPLE SCLEROSIS: REPORT BY THE PANEL ON THE EVALUATION OF EXPERIMENTAL TRIALS OF THERAPY IN MULTIPLE SCLEROSIS. Ann N Y Acad Sci. 1965; 122:552-68. DOI: 10.1111/j.1749-6632.1965.tb20235.x. View

Bellamy A, Calder V, Feldmann M, Davison A . The distribution of interleukin-2 receptor bearing lymphocytes in multiple sclerosis: evidence for a key role of activated lymphocytes. Clin Exp Immunol. 1985; 61(2):248-56. PMC: 1577300. View

Ledbetter J, Rose L, SPOONER C, Beatty P, Martin P, Clark E . Antibodies to common leukocyte antigen p220 influence human T cell proliferation by modifying IL 2 receptor expression. J Immunol. 1985; 135(3):1819-25. View

Morimoto C, Letvin N, Boyd A, Hagan M, Brown H, Kornacki M . The isolation and characterization of the human helper inducer T cell subset. J Immunol. 1985; 134(6):3762-9. View

Takeuchi T, Schlossman S, Morimoto C . The 2H4 molecule but not the T3-receptor complex is involved in suppressor inducer signals in the AMLR system. Cell Immunol. 1987; 107(1):107-14. DOI: 10.1016/0008-8749(87)90270-x. View

Budd R, Cerottini J, MacDonald H . Phenotypic identification of memory cytolytic T lymphocytes in a subset of Lyt-2+ cells. J Immunol. 1987; 138(4):1009-13. View

Serra H, Krowka J, Ledbetter J, Pilarski L . Loss of CD45R (Lp220) represents a post-thymic T cell differentiation event. J Immunol. 1988; 140(5):1435-41. View

Tedder T, Cooper M, Clement L . Human lymphocyte differentiation antigens HB-10 and HB-11. II. Differential production of B cell growth and differentiation factors by distinct helper T cell subpopulations. J Immunol. 1985; 134(5):2989-94. View

CALDWELL C, Taylor H . A rapid, no-wash technic for immunophenotypic analysis by flow cytometry. Am J Clin Pathol. 1986; 86(5):600-7. DOI: 10.1093/ajcp/86.5.600. View

10.

Rohowsky-Kochan C, Eiman D, Troiano R, Bansil S, Oleske J, Denny T . Decreased suppressor-inducer T lymphocytes in multiple sclerosis and other neurological diseases. J Neuroimmunol. 1990; 28(2):161-6. DOI: 10.1016/0165-5728(90)90030-q. View

11.

Traugott U, Reinherz E, Raine C . Multiple sclerosis: distribution of T cell subsets within active chronic lesions. Science. 1983; 219(4582):308-10. DOI: 10.1126/science.6217550. View

12.

Rose L, Ginsberg A, Rothstein T, Ledbetter J, Clark E . Fluctuations of CD4+ T-cell subsets in remitting-relapsing multiple sclerosis. Ann Neurol. 1988; 24(2):192-9. DOI: 10.1002/ana.410240204. View

13.

Hofman F, von Hanwehr R, Dinarello C, Mizel S, Hinton D, Merrill J . Immunoregulatory molecules and IL 2 receptors identified in multiple sclerosis brain. J Immunol. 1986; 136(9):3239-45. View

14.

Akbar A, Terry L, Timms A, Beverley P, Janossy G . Loss of CD45R and gain of UCHL1 reactivity is a feature of primed T cells. J Immunol. 1988; 140(7):2171-8. View

15.

Beverley P . Is T-cell memory maintained by crossreactive stimulation?. Immunol Today. 1990; 11(6):203-5. DOI: 10.1016/0167-5699(90)90083-l. View

16.

Cantrell D, Smith K . Transient expression of interleukin 2 receptors. Consequences for T cell growth. J Exp Med. 1983; 158(6):1895-911. PMC: 2187178. DOI: 10.1084/jem.158.6.1895. View

17.

Clement L, Yamashita N, Martin A . The functionally distinct subpopulations of human CD4+ helper/inducer T lymphocytes defined by anti-CD45R antibodies derive sequentially from a differentiation pathway that is regulated by activation-dependent post-thymic differentiation. J Immunol. 1988; 141(5):1464-70. View

18.

Morimoto C, Hafler D, Weiner H, Letvin N, Hagan M, Daley J . Selective loss of the suppressor-inducer T-cell subset in progressive multiple sclerosis. Analysis with anti-2H4 monoclonal antibody. N Engl J Med. 1987; 316(2):67-72. DOI: 10.1056/NEJM198701083160202. View

19.

McFarlin D, McFarland H . Multiple sclerosis (first of two parts). N Engl J Med. 1982; 307(19):1183-8. DOI: 10.1056/NEJM198211043071905. View

20.

Kurtzke J . Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). Neurology. 1983; 33(11):1444-52. DOI: 10.1212/wnl.33.11.1444. View