Low-dose Inhalation Nitric Oxide in Persistent Pulmonary Hypertension of the Newborn

Overview

Journal Lancet

Publisher Elsevier

Specialty General Medicine

Date 1992 Oct 3

PMID 1357246

Citations 107

Authors

J P Kinsella

S R Neish

E Shaffer

S H Abman

Affiliations

Soon will be listed here.

Abstract

We studied the effects of inhaled nitric oxide (NO) in 9 newborn infants with severe persistent pulmonary hypertension (PPHN) who were candidates for extracorporeal membrane oxygenation treatment. With low doses of NO (10-20 ppm) all showed rapid improvement in oxygenation without reduction of systemic blood pressure. In 6 infants treated with inhaled NO for 24 h, clinical improvement was sustained at 6 ppm.

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