Haemorrhagic Fever with Renal Syndrome, Virological and Epidemiological Aspects

Overview

Journal Pediatr Nephrol

Specialties Nephrology
Pediatrics

Date 1992 Mar 1

PMID 1349231

Citations 6

Authors

B S Niklasson

Affiliations

Soon will be listed here.

Abstract

Haemorrhagic fever with renal syndrome (HFRS) is characterized by fever, headache, abdominal pain, renal dysfunction and various haemorrhagic manifestations. The viruses causing HFRS all belong to the Hantavirus genus in the Bunyaviridae family. At least three of the different hantaviruses are associated with human disease: Hantaan, Seoul, and Puumala viruses. HFRS is endemic in a belt from Norway in the west, through Sweden, Finland, the Soviet Union, China, Korea to Japan in the east. The clinical severity of HFRS varies throughout this belt. A severe form with haemorrhagic manifestations and significant lethality (Korean haemorrhagic fever--caused by Hantaan and Seoul virus) occurs in Asia, while a milder form (nephropathia epidemica caused by Puumala virus) with less haemorrhagic manifestations and no or low lethality is found in Europe. All hantaviruses are spread by rodents where the major route of transmission to man is via aerosol from rodent urine, saliva and faeces. Although HFRS occurs with the same clinical picture in children as in adults both incidence rates and antibody prevalence rates are very low in children under 10 years. Men of working age make up the bulk of clinical cases.

Citing Articles

Serum Cytokine Profiles Differentiating Hemorrhagic Fever with Renal Syndrome and Hantavirus Pulmonary Syndrome.

Khaiboullina S, Levis S, Morzunov S, Martynova E, Anokhin V, Gusev O Front Immunol. 2017; 8:567.

PMID: 28572804 PMC: 5435745. DOI: 10.3389/fimmu.2017.00567.

Preparation and evaluation of recombinant severe fever with thrombocytopenia syndrome virus nucleocapsid protein for detection of total antibodies in human and animal sera by double-antigen sandwich enzyme-linked immunosorbent assay.

Jiao Y, Zeng X, Guo X, Qi X, Zhang X, Shi Z J Clin Microbiol. 2011; 50(2):372-7.

PMID: 22135253 PMC: 3264160. DOI: 10.1128/JCM.01319-11.

Specific humoral reaction of hemorrhagic fever with renal syndrome (HFRS) patients in China to recombinant nucleocapsid proteins from European hantaviruses.

Xiong H, Li Q, Chen W, Liu D, Ling J, Liu J Eur J Clin Microbiol Infect Dis. 2011; 30(5):645-51.

PMID: 21222012 DOI: 10.1007/s10096-010-1134-5.

New ecological aspects of hantavirus infection: a change of a paradigm and a challenge of prevention--a review.

Zeier M, Handermann M, Bahr U, Rensch B, Muller S, Kehm R Virus Genes. 2005; 30(2):157-80.

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A patient with Down's syndrome and anti-neutrophilic cytoplasmic antibody-positive vasculitis.

Schwab M, Boswald M, Ludwig K, Wittekind C, Waldherr R, Ruder H Pediatr Nephrol. 1996; 10(2):249-50.

PMID: 8703724 DOI: 10.1007/BF00862096.

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