Autocrine Growth Induced by Kinase Type Oncogenes in Myeloid Cells Requires AP-1 and NF-M, a Myeloid Specific, C/EBP-like Factor

Overview

Journal EMBO J

Specialties Biotechnology
Molecular Biology

Date 1992 Jan 1

PMID 1346759

Citations 38

Authors

E Sterneck

C Muller

S Katz

A Leutz

Affiliations

Soon will be listed here.

Abstract

The nuclear oncogenes v-myc or v-myb specifically transform avian myeloid cells. In both cases, the transformed cells remain dependent on chicken myelomonocytic growth factor (cMGF). This factor dependence can be relieved by expression of kinase-type oncogenes such as v-mil or v-erbB, leading to expression of cMGF and autocrine growth stimulation. In erythroid cells the same kinase-type oncogenes cause transformation but do not induce cMGF expression. Here we investigated the molecular mechanisms of the observed lineage specific oncogene collaboration. We found that kinase-type oncogenes and TPA activate the cMGF promoter via AP-1 like transcription factors. The activation of the cMGF promoter is, however, strictly dependent on the binding of nuclear proteins to both halves of an inverted repeat adjacent to the AP-1 binding site. These proteins are related to C/EBP. They are expressed exclusively in myeloid cells and were therefore termed NF-M. Our results indicate that the lineage specific cooperation of kinase type oncogenes with v-myb or v-myc in leukemia formation is based on the concerted action of AP-1 and NF-M on the cMGF promoter.

Citing Articles

BestCRM: An Exhaustive Search for Optimal Cis-Regulatory Modules in Promoters Accelerated by the Multidimensional Hash Function.

Deyneko I Int J Mol Sci. 2024; 25(3).

PMID: 38339181 PMC: 10856692. DOI: 10.3390/ijms25031903.

C/EBPβ regulates homeostatic and oncogenic gastric cell proliferation.

Regalo G, Forster S, Resende C, Bauer B, Fleige B, Kemmner W J Mol Med (Berl). 2016; 94(12):1385-1395.

PMID: 27522676 PMC: 5143359. DOI: 10.1007/s00109-016-1447-7.

MatrixCatch--a novel tool for the recognition of composite regulatory elements in promoters.

Deyneko I, Kel A, Kel-Margoulis O, Deineko E, Wingender E, Weiss S BMC Bioinformatics. 2013; 14:241.

PMID: 23924163 PMC: 3754795. DOI: 10.1186/1471-2105-14-241.

Repression of transcriptional activity of C/EBPalpha by E2F-dimerization partner complexes.

Zaragoza K, Begay V, Schuetz A, Heinemann U, Leutz A Mol Cell Biol. 2010; 30(9):2293-304.

PMID: 20176812 PMC: 2863587. DOI: 10.1128/MCB.01619-09.

Identification of interacting transcription factors regulating tissue gene expression in human.

Hu Z, Gallo S BMC Genomics. 2010; 11:49.

PMID: 20085649 PMC: 2822763. DOI: 10.1186/1471-2164-11-49.

References

Graf T, OKER-BLOM N, TODOROV T, Beug H . Transforming capacities and defectiveness of avian leukemia viruses OK10 and E 26. Virology. 1979; 99(2):431-6. DOI: 10.1016/0042-6822(79)90024-2. View

Imler J, Ugarte E, Wasylyk C, Wasylyk B . v-jun is a transcriptional activator, but not in all cell-lines. Nucleic Acids Res. 1988; 16(7):3005-12. PMC: 336447. DOI: 10.1093/nar/16.7.3005. View

Ryseck R, Bravo R . c-JUN, JUN B, and JUN D differ in their binding affinities to AP-1 and CRE consensus sequences: effect of FOS proteins. Oncogene. 1991; 6(4):533-42. View

Nakabeppu Y, Nathans D . A naturally occurring truncated form of FosB that inhibits Fos/Jun transcriptional activity. Cell. 1991; 64(4):751-9. DOI: 10.1016/0092-8674(91)90504-r. View

Binetruy B, Smeal T, Karin M . Ha-Ras augments c-Jun activity and stimulates phosphorylation of its activation domain. Nature. 1991; 351(6322):122-7. DOI: 10.1038/351122a0. View

Baichwal V, Park A, Tjian R . v-Src and EJ Ras alleviate repression of c-Jun by a cell-specific inhibitor. Nature. 1991; 352(6331):165-8. DOI: 10.1038/352165a0. View

Akira S, Isshiki H, Sugita T, TANABE O, Kinoshita S, Nishio Y . A nuclear factor for IL-6 expression (NF-IL6) is a member of a C/EBP family. EMBO J. 1990; 9(6):1897-906. PMC: 551896. DOI: 10.1002/j.1460-2075.1990.tb08316.x. View

Benbrook D, Jones N . Heterodimer formation between CREB and JUN proteins. Oncogene. 1990; 5(3):295-302. View

Velcich A, Ziff E . Functional analysis of an isolated fos promoter element with AP-1 site homology reveals cell type-specific transcriptional properties. Mol Cell Biol. 1990; 10(12):6273-82. PMC: 362902. DOI: 10.1128/mcb.10.12.6273-6282.1990. View

10.

Ziff E . Transcription factors: a new family gathers at the cAMP response site. Trends Genet. 1990; 6(3):69-72. DOI: 10.1016/0168-9525(90)90081-g. View

11.

Gutman A, Wasylyk B . The collagenase gene promoter contains a TPA and oncogene-responsive unit encompassing the PEA3 and AP-1 binding sites. EMBO J. 1990; 9(7):2241-6. PMC: 551948. DOI: 10.1002/j.1460-2075.1990.tb07394.x. View

12.

Descombes P, Chojkier M, LICHTSTEINER S, Falvey E, Schibler U . LAP, a novel member of the C/EBP gene family, encodes a liver-enriched transcriptional activator protein. Genes Dev. 1990; 4(9):1541-51. DOI: 10.1101/gad.4.9.1541. View

13.

Cohen D, Ferreira P, Gentz R, Franza Jr B, Curran T . The product of a fos-related gene, fra-1, binds cooperatively to the AP-1 site with Jun: transcription factor AP-1 is comprised of multiple protein complexes. Genes Dev. 1989; 3(2):173-84. DOI: 10.1101/gad.3.2.173. View

14.

Herrera R, Ro H, Robinson G, Xanthopoulos K, Spiegelman B . A direct role for C/EBP and the AP-I-binding site in gene expression linked to adipocyte differentiation. Mol Cell Biol. 1989; 9(12):5331-9. PMC: 363701. DOI: 10.1128/mcb.9.12.5331-5339.1989. View

15.

Nelson R, Long G . A general method of site-specific mutagenesis using a modification of the Thermus aquaticus polymerase chain reaction. Anal Biochem. 1989; 180(1):147-51. DOI: 10.1016/0003-2697(89)90103-6. View

16.

Friedman A, Landschulz W, McKnight S . CCAAT/enhancer binding protein activates the promoter of the serum albumin gene in cultured hepatoma cells. Genes Dev. 1989; 3(9):1314-22. DOI: 10.1101/gad.3.9.1314. View

17.

Herrlich P, Ponta H . 'Nuclear' oncogenes convert extracellular stimuli into changes in the genetic program. Trends Genet. 1989; 5(4):112-5. DOI: 10.1016/0168-9525(89)90041-3. View

18.

Schreiber E, Matthias P, Muller M, Schaffner W . Rapid detection of octamer binding proteins with 'mini-extracts', prepared from a small number of cells. Nucleic Acids Res. 1989; 17(15):6419. PMC: 318318. DOI: 10.1093/nar/17.15.6419. View

19.

Johnson P, Landschulz W, Graves B, McKnight S . Identification of a rat liver nuclear protein that binds to the enhancer core element of three animal viruses. Genes Dev. 1987; 1(2):133-46. DOI: 10.1101/gad.1.2.133. View

20.

Jansson M, Beug H, Gray C, Graf T, Vennstrom B . Defective v-erbB genes can be complemented by v-erbA in erythroblast and fibroblast transformation. Oncogene. 1987; 1(2):167-73. View