On the Role of Interleukin-2 (IL-2) in Multiple Sclerosis (MS). IL-2-mediated Endothelial Cell Activation

Overview

Journal Ital J Neurol Sci

Specialty Neurology

Date 1992 Dec 1

PMID 1345742

Citations 5

Authors

P Gallo

S Pagni

M G Piccinno

B Giometto

V Argentiero

M Chiusole

F Bozza

B Tavolato

Affiliations

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Abstract

Increased serum levels of IL-2 and sIL-2R can be demonstrated in patients with active MS, a finding that strongly supports the hypothesis of a systemic T cell activation in such patients. However, IL-2 may play a crucial role in MS immunopathology by activating endothelial cells, as suggested by the vascular leak syndrome complicating hrIL-2 therapy. Early BBB impairment and focal perivascular edema that characterize MS lesions may be the effect of an IL-2-induced cytokine cascade.

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