Genomic Rearrangements in Human Rotavirus Strain Wa; Analysis of Rearranged RNA Segment 7

Overview

Journal Arch Virol

Specialty Microbiology

Date 1992 Jan 1

PMID 1339264

Citations 7

Authors

E Mendez

C F Arias

S Lopez

Affiliations

Soon will be listed here.

Abstract

Two rotavirus variants containing genomic rearrangements were isolated from human rotavirus strain Wa. In one variant (H5) the rearrangement involves the RNA segment 5, while in the other variant (H57) two genes, 5 and 7 are rearranged. The rearranged genes are composed exclusively of sequences from the genes they substitute. Sequence analysis of the rearranged segment 7 indicated that it is a partial duplication of the wild type gene, in a head-to-tail orientation.

Citing Articles

CRISPR-Csy4-Mediated Editing of Rotavirus Double-Stranded RNA Genome.

Papa G, Venditti L, Braga L, Schneider E, Giacca M, Petris G Cell Rep. 2020; 32(13):108205.

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Rotavirus rearranged genomic RNA segments are preferentially packaged into viruses despite not conferring selective growth advantage to viruses.

Troupin C, Schnuriger A, Duponchel S, Deback C, Schnepf N, Dehee A PLoS One. 2011; 6(5):e20080.

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Rearranged genomic RNA segments offer a new approach to the reverse genetics of rotaviruses.

Troupin C, Dehee A, Schnuriger A, Vende P, Poncet D, Garbarg-Chenon A J Virol. 2010; 84(13):6711-9.

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Rearrangements of rotavirus genomic segment 11 are generated during acute infection of immunocompetent children and do not occur at random.

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A human rotavirus with rearranged genes 7 and 11 encodes a modified NSP3 protein and suggests an additional mechanism for gene rearrangement.

Gault E, Schnepf N, Poncet D, Servant A, Teran S, Garbarg-Chenon A J Virol. 2001; 75(16):7305-14.

PMID: 11462002 PMC: 114965. DOI: 10.1128/JVI.75.16.7305-7314.2001.

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