Effect of 1-methyl-1-nitrosourea and Streptozotocin on Glucose-induced Insulin Secretion by Isolated Islets of Langerhans

Overview

Journal Diabetologia

Specialty Endocrinology

Date 1976 Jul 1

PMID 133846

Citations 4

Authors

P Golden

L Baird

W J Malaisse

F Malaisse-Lagae

M M Walker

Affiliations

Soon will be listed here.

Abstract

The present experiments were designed to compare the effects of streptozotocin and 1-methyl-1-nitrosourea upon glucose-induced insulin secretion by isolated islets of Langerhans. Both drugs depressed the insulin response at one and two hours incubation but higher molar concentrations of the nitrosourea were required to produce the same level of inhibition as streptozotocin, a difference perhaps related to the latter's glucose moiety.

Citing Articles

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The potential mechanism of the diabetogenic action of streptozotocin: inhibition of pancreatic beta-cell O-GlcNAc-selective N-acetyl-beta-D-glucosaminidase.

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Strategies for reduction in the prevalence of NIDDM; the case for a population-based approach to the development of policies to deal with environmental factors in its aetiology.

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Streptozotocin-induced FAD-glycerophosphate dehydrogenase suppression in pancreatic islets. Relationship with the severity and duration of hyperglycaemia and resistance to insulin or riboflavin treatment.

Rasschaert J, Malaisse W Acta Diabetol. 1993; 30(1):6-10.

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