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Synthetic Substances with Morphine-like Effect; Relationship Between Analgesic Action and Addiction Liability, with a Discussion of the Chemical Structure of Addiction-producing Substances

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Specialty Public Health
Date 1956 Jan 1
PMID 13342924
Citations 18
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Abstract

For compounds of the morphine, morphinan, pethidine, hexamethyleneimine, methadone, and dithienylbutenylamine groups, the analgesic and physical-dependence-producing properties are compared. On the basis of a parellelism in intensity of these properties, conclusions are drawn regarding their interrelationship and the chemical features common to substances with morphine-like addiction liability.

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