Basonuclin: a Keratinocyte Protein with Multiple Paired Zinc Fingers

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 1992 Nov 1

PMID 1332044

Citations 29

Authors

H Tseng

H Green

Affiliations

Soon will be listed here.

Abstract

A cDNA clone has been prepared from mRNA of cultured human keratinocytes. The sequence of the cDNA reveals that in the C-terminal two-thirds of the corresponding protein (basonuclin), there are three separated pairs of adjacent zinc fingers. The amino acid sequence of each pair is homologous to that of the single pair of zinc fingers of the Drosophila transcription factor encoded by disco. Near the C-terminal end of basonuclin and on the surface of a putative alpha-helix, there is a stripe of serine residues similar to that of the transcription factor PRDII-BF1. Basonuclin possesses a sequence of six amino acids quite similar to one present in the myogenic family of proteins, including Myf5; this sequence is located in the omega loop of the myogenic proteins but within a zinc finger of the keratinocyte protein. As basonuclin is present mainly in the nuclei of the basal cell layer, its regulatory function is likely to be exerted prior to the process of terminal differentiation.

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References

Weintraub H, Davis R, Tapscott S, Thayer M, Krause M, Benezra R . The myoD gene family: nodal point during specification of the muscle cell lineage. Science. 1991; 251(4995):761-6. DOI: 10.1126/science.1846704. View

Blok J, Air G . Sequence variation at the 3' end of the neuraminidase gene from 39 influenza type A viruses. Virology. 1982; 121(2):211-29. DOI: 10.1016/0042-6822(82)90162-3. View

Harrison S . A structural taxonomy of DNA-binding domains. Nature. 1991; 353(6346):715-9. DOI: 10.1038/353715a0. View

Fan C, Maniatis T . A DNA-binding protein containing two widely separated zinc finger motifs that recognize the same DNA sequence. Genes Dev. 1990; 4(1):29-42. DOI: 10.1101/gad.4.1.29. View

Davis R, Cheng P, Lassar A, Weintraub H . The MyoD DNA binding domain contains a recognition code for muscle-specific gene activation. Cell. 1990; 60(5):733-46. DOI: 10.1016/0092-8674(90)90088-v. View

Benezra R, Davis R, Lockshon D, Turner D, Weintraub H . The protein Id: a negative regulator of helix-loop-helix DNA binding proteins. Cell. 1990; 61(1):49-59. DOI: 10.1016/0092-8674(90)90214-y. View

Barrandon Y, Green H . Three clonal types of keratinocyte with different capacities for multiplication. Proc Natl Acad Sci U S A. 1987; 84(8):2302-6. PMC: 304638. DOI: 10.1073/pnas.84.8.2302. View

Lee M, Gippert G, Soman K, Case D, Wright P . Three-dimensional solution structure of a single zinc finger DNA-binding domain. Science. 1989; 245(4918):635-7. DOI: 10.1126/science.2503871. View

Dang C, Lee W . Nuclear and nucleolar targeting sequences of c-erb-A, c-myb, N-myc, p53, HSP70, and HIV tat proteins. J Biol Chem. 1989; 264(30):18019-23. View

10.

Simon M, Green H . Enzymatic cross-linking of involucrin and other proteins by keratinocyte particulates in vitro. Cell. 1985; 40(3):677-83. DOI: 10.1016/0092-8674(85)90216-8. View

11.

Kozak M . The scanning model for translation: an update. J Cell Biol. 1989; 108(2):229-41. PMC: 2115416. DOI: 10.1083/jcb.108.2.229. View

12.

Braun T, Bober E, Tannich E, Arnold H . A novel human muscle factor related to but distinct from MyoD1 induces myogenic conversion in 10T1/2 fibroblasts. EMBO J. 1989; 8(3):701-9. PMC: 400865. DOI: 10.1002/j.1460-2075.1989.tb03429.x. View

13.

Weintraub H, Tapscott S, Davis R, Thayer M, Adam M, Lassar A . Activation of muscle-specific genes in pigment, nerve, fat, liver, and fibroblast cell lines by forced expression of MyoD. Proc Natl Acad Sci U S A. 1989; 86(14):5434-8. PMC: 297637. DOI: 10.1073/pnas.86.14.5434. View

14.

Berg J . Proposed structure for the zinc-binding domains from transcription factor IIIA and related proteins. Proc Natl Acad Sci U S A. 1988; 85(1):99-102. PMC: 279490. DOI: 10.1073/pnas.85.1.99. View

15.

Pearson W, Lipman D . Improved tools for biological sequence comparison. Proc Natl Acad Sci U S A. 1988; 85(8):2444-8. PMC: 280013. DOI: 10.1073/pnas.85.8.2444. View

16.

Air G, Webster R, Colman P, Laver W . Distribution of sequence differences in influenza N9 neuraminidase of tern and whale viruses and crystallization of the whale neuraminidase complexed with antibodies. Virology. 1987; 160(2):346-54. DOI: 10.1016/0042-6822(87)90005-5. View

17.

Leszczynski J, Rose G . Loops in globular proteins: a novel category of secondary structure. Science. 1986; 234(4778):849-55. DOI: 10.1126/science.3775366. View

18.

Rheinwald J . Polycyclic aromatic hydrocarbon mutagenesis of human epidermal keratinocytes in culture. Proc Natl Acad Sci U S A. 1984; 81(24):7802-6. PMC: 392240. DOI: 10.1073/pnas.81.24.7802. View

19.

Rheinwald J, Green H . Serial cultivation of strains of human epidermal keratinocytes: the formation of keratinizing colonies from single cells. Cell. 1975; 6(3):331-43. DOI: 10.1016/s0092-8674(75)80001-8. View

20.

KELLER A, Maniatis T . Only two of the five zinc fingers of the eukaryotic transcriptional repressor PRDI-BF1 are required for sequence-specific DNA binding. Mol Cell Biol. 1992; 12(5):1940-9. PMC: 364364. DOI: 10.1128/mcb.12.5.1940-1949.1992. View