A Mouse Mammary Tumor Virus Mammary Gland Enhancer Confers Tissue-specific but Not Lactation-dependent Expression in Transgenic Mice

Overview

Journal J Virol

Publisher American Society for Microbiology

Date 1992 Dec 1

PMID 1331537

Citations 20

Authors

E Mok

T V Golovkina

S R Ross

Affiliations

Soon will be listed here.

Abstract

The long terminal repeat (LTR) of mouse mammary tumor virus (MMTV) is known to contain a number of transcriptional regulatory elements, including glucocorticoid response elements. In this study, we showed that a mammary gland/salivary gland enhancer found in the LTR of this virus directs expression of a heterologous promoter to both virgin and lactating mammary glands in transgenic mice. Using transgenic mice containing hybrid gene constructs with various deletions of the LTR sequences linked to marker genes, we also showed that the dramatic increase in MMTV expression that occurs during lactation is due to the glucocorticoid response elements. Thus, the MMTV LTR encodes two distinct elements, both of which are required for a high level of expression in lactating mammary glands.

Citing Articles

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Mouse Mammary Tumor Virus (MMTV) and MMTV-like Viruses: An In-depth Look at a Controversial Issue.

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Regulation of Expression and Latency in BLV and HTLV.

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MMTV does not encode viral microRNAs but alters the levels of cancer-associated host microRNAs.

Kincaid R, Panicker N, Lozano M, Sullivan C, Dudley J, Mustafa F Virology. 2017; 513:180-187.

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MMTV infectious cycle and the contribution of virus-encoded proteins to transformation of mammary tissue.

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