Serotonin Enhances the Beta-adrenergic Response in Rat Brain Cortical Slices

Overview

Journal Eur J Pharmacol

Specialty Pharmacology

Date 1992 Mar 12

PMID 1325368

Citations 8

Authors

D Morin

R Sapena

R Zini

J P Tillement

Affiliations

Soon will be listed here.

Abstract

Serotonin increased the isoproterenol-induced cyclic AMP accumulation in rat brain cortical slices but did not itself stimulate the production of cyclic AMP in this area. This effect appeared to be inhibited by the 5-HT2 receptor antagonist, ritanserin. This potentiation was not observed in the hippocampus. These data reinforce the hypothesis of a coupling between the noradrenergic and serotonergic systems, which may be involved in the mechanism of action of antidepressant drugs.

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