Oxygen Free Radical Producing Activity of Polymorphonuclear Leukocytes in Patients with Parkinson's Disease

Overview

Journal Mol Cell Biochem

Publisher Springer

Specialty Biochemistry

Date 1992 Jun 26

PMID 1322491

Citations 7

Authors

J Kalra

A H Rajput

S V Mantha

A K Chaudhary

K Prasad

Affiliations

Soon will be listed here.

Abstract

Oxygen free radicals (OFRs) have been suggested in the pathogenesis of Parkinson's disease (PD). These free radicals exert their cytotoxic effect by peroxidation of lipid membrane resulting in the formation of malondialdehyde (MDA). Polymorphonuclear (PMN) leukocyte is one of the major sources of OFR. However, the oxygen free radical producing activity of PMN leukocytes in patients with PD is not known. We therefore studied the oxygen free radical producing activity of polymorphonuclear leukocytes and MDA levels in the serum of healthy subjects and in patients with Parkinson's disease. The oxygen free radical producing activity of PMN leukocytes in blood and the MDA content in serum were significantly higher in patients with Parkinson's disease than in healthy subjects. These results indicate a possible role of oxygen free radicals in the pathogenesis of Parkinson's disease.

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