Selective Expansion of T Cells Expressing T-cell Receptor Variable Regions V Beta 2 and V Beta 8 in Kawasaki Disease

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 1992 May 1

PMID 1315049

Citations 101

Authors

J Abe

B L Kotzin

K Jujo

M E Melish

M P Glode

T Kohsaka

D Y Leung

Affiliations

Soon will be listed here.

Abstract

Kawasaki disease (KD) is an acute vasculitis complicated by the development of coronary artery abnormalities. The etiology of KD is unknown. Based on the observation that KD is associated with marked activation of T cells and monocyte/macrophages, we hypothesized that KD may be caused by a superantigen [e.g., a bacterial toxin that stimulates T cells expressing particular T-cell receptor beta chain variable (V beta) gene segments]. Peripheral blood T cells from patients in the acute and convalescent phases of KD and from various control groups were analyzed for T-cell receptor V beta gene expression by using a quantitative PCR technique and cytofluorographic analysis with available anti-V beta monoclonal antibodies. Patients with acute KD demonstrated significantly elevated levels of circulating V beta 2+ and V beta 8.1+ T cells compared to the other control groups. none of the other 20 V beta populations analyzed by quantitative PCR were found to be significantly elevated. Using flow cytometry, we confirmed a significant elevation of T cells reactive with anti-V beta 8.1 and the lack of change in several other V beta subsets--i.e. V beta 5.1, -5.2, -6.7, and -12. During the convalescence phase of KD, there was a reduction in the abnormal levels of V beta 2+ and V beta 8.1+ T cells. These observations suggest that KD may be caused by a superantigen and may provide insight into the nature of the etiologic agent.

Citing Articles

Kawasaki Disease-Associated Cytokine Storm Syndrome.

Tsoukas P, Yeung R Adv Exp Med Biol. 2024; 1448:365-383.

PMID: 39117827 DOI: 10.1007/978-3-031-59815-9_25.

The superantigens SpeC and TSST-1 specifically activate TRBV12-3/12-4 memory T cells.

Shepherd F, Davies K, Miners K, Llewellyn-Lacey S, Kollnberger S, Redman J Commun Biol. 2023; 6(1):78.

PMID: 36670205 PMC: 9854414. DOI: 10.1038/s42003-023-04420-1.

Acute Appendicitis Associated With Kawasaki Disease: Case Report and Review of the Literature.

Kuroda K, Stottlemyre M Cureus. 2021; 13(10):e18997.

PMID: 34853740 PMC: 8608400. DOI: 10.7759/cureus.18997.

Multisystem inflammatory syndrome in children and Kawasaki disease: a critical comparison.

Sharma C, Ganigara M, Galeotti C, Burns J, Berganza F, Hayes D Nat Rev Rheumatol. 2021; 17(12):731-748.

PMID: 34716418 PMC: 8554518. DOI: 10.1038/s41584-021-00709-9.

Single-cell RNA sequencing of peripheral blood mononuclear cells from acute Kawasaki disease patients.

Wang Z, Xie L, Ding G, Song S, Chen L, Li G Nat Commun. 2021; 12(1):5444.

PMID: 34521850 PMC: 8440575. DOI: 10.1038/s41467-021-25771-5.

References

LANG B, Silverman E, Laxer R, Lau A . Spontaneous tumor necrosis factor production in Kawasaki disease. J Pediatr. 1989; 115(6):939-43. DOI: 10.1016/s0022-3476(89)80746-2. View

Mantovani A, Dejana E . Cytokines as communication signals between leukocytes and endothelial cells. Immunol Today. 1989; 10(11):370-5. DOI: 10.1016/0167-5699(89)90270-3. View

Rauch A, Hurwitz E . Centers for Disease Control (CDC) case definition for Kawasaki syndrome. Pediatr Infect Dis. 1985; 4(6):702-3. DOI: 10.1097/00006454-198511000-00029. View

Rowley A, Shulman S, Preble O, Poiesz B, Ehrlich G, Sullivan J . Serum interferon concentrations and retroviral serology in Kawasaki syndrome. Pediatr Infect Dis J. 1988; 7(9):663-6. View

Posnett D, Wang C, Friedman S . Inherited polymorphism of the human T-cell antigen receptor detected by a monoclonal antibody. Proc Natl Acad Sci U S A. 1986; 83(20):7888-92. PMC: 386828. DOI: 10.1073/pnas.83.20.7888. View

Leung D, Geha R, Newburger J, Burns J, Fiers W, Lapierre L . Two monokines, interleukin 1 and tumor necrosis factor, render cultured vascular endothelial cells susceptible to lysis by antibodies circulating during Kawasaki syndrome. J Exp Med. 1986; 164(6):1958-72. PMC: 2188474. DOI: 10.1084/jem.164.6.1958. View

Furusho K, Kamiya T, Nakano H, Kiyosawa N, Shinomiya K, Hayashidera T . High-dose intravenous gammaglobulin for Kawasaki disease. Lancet. 1984; 2(8411):1055-8. DOI: 10.1016/s0140-6736(84)91504-6. View

Leung D . Immunologic aspects of Kawasaki syndrome. J Rheumatol Suppl. 1990; 24:15-8. View

Matsubara T, Furukawa S, YABUTA K . Serum levels of tumor necrosis factor, interleukin 2 receptor, and interferon-gamma in Kawasaki disease involved coronary-artery lesions. Clin Immunol Immunopathol. 1990; 56(1):29-36. DOI: 10.1016/0090-1229(90)90166-n. View

10.

Terai M, Kohno Y, Namba M, Umemiya T, Niwa K, Nakajima H . Class II major histocompatibility antigen expression on coronary arterial endothelium in a patient with Kawasaki disease. Hum Pathol. 1990; 21(2):231-4. DOI: 10.1016/0046-8177(90)90135-r. View

11.

Abe Y, Nakano S, Nakahara T, Kamezawa Y, Kato I, Ushijima H . Detection of serum antibody by the antimitogen assay against streptococcal erythrogenic toxins. Age distribution in children and the relation to Kawasaki disease. Pediatr Res. 1990; 27(1):11-5. DOI: 10.1203/00006450-199001000-00003. View

12.

Yssel H, Blanchard D, Boylston A, De Vries J, Spits H . T cell clones which share T cell receptor epitopes differ in phenotype, function and specificity. Eur J Immunol. 1986; 16(10):1187-93. DOI: 10.1002/eji.1830161002. View

13.

Nagashima M, Matsushima M, Matsuoka H, Ogawa A, Okumura N . High-dose gammaglobulin therapy for Kawasaki disease. J Pediatr. 1987; 110(5):710-2. DOI: 10.1016/s0022-3476(87)80007-0. View

14.

Rowley A, Duffy C, Shulman S . Prevention of giant coronary artery aneurysms in Kawasaki disease by intravenous gamma globulin therapy. J Pediatr. 1988; 113(2):290-4. DOI: 10.1016/s0022-3476(88)80267-1. View

15.

Leung D, COTRAN R, Kurt-Jones E, Burns J, Newburger J, Pober J . Endothelial cell activation and high interleukin-1 secretion in the pathogenesis of acute Kawasaki disease. Lancet. 1989; 2(8675):1298-302. DOI: 10.1016/s0140-6736(89)91910-7. View

16.

Kappler J, Kotzin B, Herron L, Gelfand E, Bigler R, Boylston A . V beta-specific stimulation of human T cells by staphylococcal toxins. Science. 1989; 244(4906):811-3. DOI: 10.1126/science.2524876. View

17.

Maury C, Salo E, Pelkonen P . Elevated circulating tumor necrosis factor-alpha in patients with Kawasaki disease. J Lab Clin Med. 1989; 113(5):651-4. View

18.

Leung D, Collins T, Lapierre L, Geha R, Pober J . Immunoglobulin M antibodies present in the acute phase of Kawasaki syndrome lyse cultured vascular endothelial cells stimulated by gamma interferon. J Clin Invest. 1986; 77(5):1428-35. PMC: 424542. DOI: 10.1172/JCI112454. View

19.

Rauch A . Kawasaki syndrome: review of new epidemiologic and laboratory developments. Pediatr Infect Dis J. 1987; 6(11):1016-21. View

20.

Kawasaki T . [Acute febrile mucocutaneous syndrome with lymphoid involvement with specific desquamation of the fingers and toes in children]. Arerugi. 1967; 16(3):178-222. View