Epstein-Barr Virus-associated Gastric Adenocarcinoma

Overview

Journal Am J Pathol

Publisher Elsevier

Specialty Pathology

Date 1992 Apr 1

PMID 1314023

Citations 218

Authors

D Shibata

L M Weiss

Affiliations

Soon will be listed here.

Abstract

The Epstein-Barr virus (EBV) has been detected in certain types of lymphoma and some epithelial neoplasms including nasopharyngeal lymphoepithelioma, and rare lymphoepithelioma-like carcinomas occurring in a variety of organs including, most recently, the stomach. The authors investigated the possibility that EBV may be present not only in the rare gastric cancers that resemble nasopharyngeal lymphoepithelioma, but also in typical gastric adenocarcinoma. EBV sequences were detected in 22 of 138 (16%) cases of typical gastric adenocarcinoma by polymerase chain reaction and in situ hybridization (ISH) techniques. The EBV genomes were specifically present within the gastric carcinoma cells in an even distribution. The EBV genomes were also present in adjacent dysplastic epithelium but were absent in surrounding lymphocytes, other normal stromal cells, intestinal metaplasia, and normal gastric mucosa. The EBV genomes in the infected gastric carcinoma cells are expressed as EBV RNA was detected by ISH. EBV was most often detected in gastric tumors from men (21%) compared with women (3%). Thus some cases of gastric adenocarcinoma are EBV-associated.

Citing Articles

Epstein-Barr Virus (EBV) and Human Papilloma Virus (HPV) in Gastric Cancers, with Special Reference to Gastric Cancer at a Young Age-A Pilot Study in Poland.

Mazurek M, Jaros M, Gliwa A, Sitarz M, Dudzinska E, Zinkiewicz K Int J Mol Sci. 2025; 26(2).

PMID: 39859425 PMC: 11765604. DOI: 10.3390/ijms26020711.

The Functional Interaction Between Epstein-Barr Virus and MYC in the Pathogenesis of Burkitt Lymphoma.

Solares S, Leon J, Garcia-Gutierrez L Cancers (Basel). 2025; 16(24.

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Unlocking the Potential: Epstein-Barr Virus (EBV) in Gastric Cancer and Future Treatment Prospects, a Literature Review.

Corallo S, Lasagna A, Filippi B, Alaimo D, Tortorella A, Serra F Pathogens. 2024; 13(9).

PMID: 39338919 PMC: 11435077. DOI: 10.3390/pathogens13090728.

The Emerging Role of Ferroptosis in EBV-Associated Cancer: Implications for Cancer Therapy.

He S, Luo C, Shi F, Zhou J, Shang L Biology (Basel). 2024; 13(7).

PMID: 39056735 PMC: 11274159. DOI: 10.3390/biology13070543.

Epstein-Barr Virus and Clinico-Endoscopic Characteristics of Gastric Remnant Cancers Compared to Proximal Non-Remnant Cancers: A Population-Based Study.

Bringeland E, Vage C, Uboe A, Sando A, Mjones P, Fossmark R Cancers (Basel). 2024; 16(11).

PMID: 38893119 PMC: 11170983. DOI: 10.3390/cancers16112000.

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