Pharmacological Mediators of Various Immunological and Non-immunological Inflammatory Reactions Produced in the Pleural Cavity

Overview

Journal Agents Actions

Specialty Pharmacology

Date 1975 Dec 1

PMID 130792

Citations 8

Authors

F Capasso

C J Dunn

S Yamamoto

D A Deporter

J P Giroud

D A Willoughby

Affiliations

Soon will be listed here.

Abstract

Intrapleural exudates have been produced in rats and guinea-pigs using calcium pyrophosphate, cell mediated immunity, reversed passive Arthus reaction and carrageenan. The intracellular concentration of various pharmacological mediators has been measured at different times during the evolution of these inflammatory responses. These have been correlated with volume of exudate and cellular migration. The significance of these findings has been discussed and the possible application to the search for new anti-inflammatory agents and their use in diagnostic procedures.

Citing Articles

Involvement of cyclooxygenase-2 and prostaglandins in the molecular pathogenesis of inflammatory lung diseases.

Park G, Christman J Am J Physiol Lung Cell Mol Physiol. 2006; 290(5):L797-805.

PMID: 16603593 PMC: 4358817. DOI: 10.1152/ajplung.00513.2005.

Prostaglandin F2alpha produced by inducible cyclooxygenase may contribute to the resolution of inflammation.

Colville-Nash P, Gilroy D, Willis D, Paul-Clark M, Moore A, Willoughby D Inflammopharmacology. 2005; 12(5-6):473-6.

PMID: 16259714 DOI: 10.1163/156856005774382616.

Professor Derek Albert Willoughby (1930-2004).

Rainsford K Inflammopharmacology. 2005; 12(5-6):407-39.

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The reactivity of neutrophils at the site of an acute inflammatory reaction as measured by chemiluminescence.

Bird J, Giroud J Agents Actions. 1984; 15(3-4):349-55.

PMID: 6524524 DOI: 10.1007/BF01972370.

Prostacyclin and thromboxanes in carrageenan-induced pleurisy in the rat.

Tissot M, Bonne C, Martin B, Solier M, Giroud J Agents Actions. 1984; 14(1):76-81.

PMID: 6422712 DOI: 10.1007/BF01966837.

References

Yamamoto S, Dunn C, Capasso F, Deporter D, Willoughby D . Quantitative studies on cell-mediated immunity in the pleural cavity of guinea-pigs. J Pathol. 1975; 117(2):65-73. DOI: 10.1002/path.1711170202. View

Di Rosa M, Giroud J, Willoughby D . Studies on the mediators of the acute inflammatory response induced in rats in different sites by carrageenan and turpentine. J Pathol. 1971; 104(1):15-29. DOI: 10.1002/path.1711040103. View

Capasso F, Dunn C, Yamamoto S, Willoughby D, Giroud J . Further studies on carrageenan-induced pleurisy in rats. J Pathol. 1975; 116(2):117-24. DOI: 10.1002/path.1711160208. View

Willoughby D, Dunn C, Yamamoto S, Capasso F, Deporter D, Giroud J . Calcium pyrophosphate-induced pleurisy in rats: a new model of acute inflammation. Agents Actions. 1975; 5(1):35-8. DOI: 10.1007/BF02027156. View

Willoughby D . Heberden Oration, 1974. Human arthritis applied to animal models. Towards a better therapy. Ann Rheum Dis. 1975; 34(6):471-8. PMC: 1006468. DOI: 10.1136/ard.34.6.471. View