Effects of Cimetidine and Atropine Sulfate on Gastric Secretion and Healing of Gastric and Duodenal Ulcers in Rats

Overview

Journal Eur J Pharmacol

Specialty Pharmacology

Date 1977 Jan 21

PMID 12989

Citations 10

Authors

S Okabe

K Takeuchi

T Murata

K Takagi

Affiliations

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Abstract

Cimetidine, a new histamine H2-receptor antagonist (50 or 100 mg/kg) and atropine sulfate (15 mg/kg) given intraduodenally, markedly inhibited gastric secretion in pylorus-ligated rats. Cimetidine (100 or 200 mg/kg/day) given for 10 or 12 consecutive days orally in two divided doses, significantly promoted the healing rate of both gastric and duodenal ulcers induced in rats. Atropine (30 mg/kg/day) also significantly accelerated the healing of duodenal ulcers but failed to affect gastric ulcers.

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Effect of cimetidine and carbenoxolone on cysteamine-induced ulcers: a study of gastric mucosal histamine and histamine formation capacity in rat.

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