STAT-3 Activity in Chemically-induced Hepatocellular Carcinoma

Overview

Journal Eur J Cancer

Specialty Oncology

Date 2003 Sep 6

PMID 12957465

Citations 13

Authors

A Sanchez

P Nagy

S S Thorgeirsson

Affiliations

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Abstract

The signal transducer and activator of transcription (STAT)-3 regulates basic biological processes and it has been reported to be constitutively active in different types of malignant tumours. STAT-3 is active during the regenerative growth of the liver, but there are hardly any data about its presence in liver tumours. We investigated and found a high activity of STAT-3 using an electrophoretic mobility shift assay (EMSA) in chemically-induced rat hepatocellular carcinomas (HCCs). Dexamethasone treatment downregulated both STAT-3 activity and cell proliferation in the tumours. Therefore, the activity of the STAT-3 signal transduction pathway seems to be required for the growth of HCCs and could be a potential new target for therapeutic trials of this tumour type.

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