RecQ Helicases: Multiple Roles in Genome Maintenance

Overview

Journal Trends Cell Biol

Specialty Cell Biology

Date 2003 Aug 30

PMID 12946629

Citations 62

Authors

Rakesh R Khakhar

Jennifer A Cobb

Lotte Bjergbaek

Ian D Hickson

Susan M Gasser

Affiliations

Soon will be listed here.

Abstract

The RecQ helicases are highly conserved in evolution and are required for maintaining genome stability in all organisms. In humans, loss of RecQ helicase function is associated with predisposition to cancer and/or premature ageing. Recent data show that RecQ helicases have several roles during S phase of the cell cycle, ranging from facilitating the resumption of DNA synthesis at sites of replication fork breakdown to resolving structures during the process of homologous recombination.

Citing Articles

Characterization and organization of telomeric-linked helicase (tlh) gene families in Fusarium oxysporum.

Salimi S, Abdi M, Rahnama M Curr Genet. 2024; 70(1):19.

PMID: 39528830 DOI: 10.1007/s00294-024-01303-8.

DNA helicase RecQ1 regulates mutually exclusive expression of virulence genes in via heterochromatin alteration.

Li Z, Yin S, Sun M, Cheng X, Wei J, Gilbert N Proc Natl Acad Sci U S A. 2019; 116(8):3177-3182.

PMID: 30728298 PMC: 6386683. DOI: 10.1073/pnas.1811766116.

Mechanisms for stalled replication fork stabilization: new targets for synthetic lethality strategies in cancer treatments.

Liao H, Ji F, Helleday T, Ying S EMBO Rep. 2018; 19(9).

PMID: 30108055 PMC: 6123652. DOI: 10.15252/embr.201846263.

Single molecule kinetics uncover roles for E. coli RecQ DNA helicase domains and interaction with SSB.

Bagchi D, Manosas M, Zhang W, Manthei K, Hodeib S, Ducos B Nucleic Acids Res. 2018; 46(16):8500-8515.

PMID: 30053104 PMC: 6144805. DOI: 10.1093/nar/gky647.

A helical bundle in the N-terminal domain of the BLM helicase mediates dimer and potentially hexamer formation.

Shi J, Chen W, Zhang B, Fan S, Ai X, Liu N J Biol Chem. 2017; 292(14):5909-5920.

PMID: 28228481 PMC: 5392582. DOI: 10.1074/jbc.M116.761510.