NKT Cells and HIV Infection

Overview

Journal Microbes Infect

Publisher Elsevier

Specialties Allergy & Immunology
Microbiology

Date 2003 Aug 28

PMID 12941396

Citations 11

Authors

Derya Unutmaz

Affiliations

Soon will be listed here.

Abstract

Natural killer T (NKT) cells are a subset of lymphocytes that express a semi-invariant T cell receptor (TCR) that recognizes glycolipids presented by the non-polymorphic MHC class I-like molecule CD1d. NKT cells regulate a wide variety of immune functions against autoantigens and pathogens. Recently, it was shown that NKT cells are targeted by HIV-1 and selectively lost in HIV-infected individuals. This review will focus on the mechanisms, consequences and therapeutic implications of these findings.

Citing Articles

Editorial: Role of CD1- and MR1-Restricted T Cells in Immunity and Disease.

Iwabuchi K, Van Kaer L Front Immunol. 2019; 10:1837.

PMID: 31447847 PMC: 6691045. DOI: 10.3389/fimmu.2019.01837.

HIV infection: focus on the innate immune cells.

Espindola M, Soares L, Galvao-Lima L, Zambuzi F, Cacemiro M, Brauer V Immunol Res. 2016; 64(5-6):1118-1132.

PMID: 27590022 DOI: 10.1007/s12026-016-8862-2.

Preferential depletion of gut CD4-expressing iNKT cells contributes to systemic immune activation in HIV-1 infection.

Ibarrondo F, Wilson S, Hultin L, Shih R, Hausner M, Hultin P Mucosal Immunol. 2012; 6(3):591-600.

PMID: 23149661 PMC: 3865278. DOI: 10.1038/mi.2012.101.

Loss of effector and anti-inflammatory natural killer T lymphocyte function in pathogenic simian immunodeficiency virus infection.

Rout N, Greene J, Yue S, OConnor D, Johnson R, Else J PLoS Pathog. 2012; 8(9):e1002928.

PMID: 23028326 PMC: 3447755. DOI: 10.1371/journal.ppat.1002928.

Invariant NKT cells: regulation and function during viral infection.

Juno J, Keynan Y, Fowke K PLoS Pathog. 2012; 8(8):e1002838.

PMID: 22916008 PMC: 3420949. DOI: 10.1371/journal.ppat.1002838.