» Articles » PMID: 12941205

ICD Therapy for the Prevention of Sudden Cardiac Death in Post-MI Patients

Overview
Date 2003 Aug 28
PMID 12941205
Authors
Affiliations
Soon will be listed here.
Abstract

Implantable cardioverter-defibrillators (ICDs) are unequivocally the treatment of choice for patients who have already experienced a near-fatal tachyarrhythmic event. Recently, studies have conclusively demonstrated that extending the benefits of ICD therapy to postinfarction patients with resultant left ventricular dysfunction results in dramatic additional lifesaving without the need for complex risk- stratification procedures. The landmark Multicenter Automatic Defibrillator Implantation Trial II (MADIT II) shows that patients with reduced left ventricular function (ejection fraction < 30%) 1 month after a myocardial infarction should receive an ICD to prevent sudden cardiac death.

References
1.
Connolly S, Gent M, Roberts R, Dorian P, Roy D, Sheldon R . Canadian implantable defibrillator study (CIDS) : a randomized trial of the implantable cardioverter defibrillator against amiodarone. Circulation. 2000; 101(11):1297-302. DOI: 10.1161/01.cir.101.11.1297. View

2.
BIGGER Jr J, Fleiss J, KLEIGER R, Miller J, Rolnitzky L . The relationships among ventricular arrhythmias, left ventricular dysfunction, and mortality in the 2 years after myocardial infarction. Circulation. 1984; 69(2):250-8. DOI: 10.1161/01.cir.69.2.250. View

3.
Sim I, McDonald K, Lavori P, Norbutas C, Hlatky M . Quantitative overview of randomized trials of amiodarone to prevent sudden cardiac death. Circulation. 1997; 96(9):2823-9. DOI: 10.1161/01.cir.96.9.2823. View

4.
. A comparison of antiarrhythmic-drug therapy with implantable defibrillators in patients resuscitated from near-fatal ventricular arrhythmias. N Engl J Med. 1997; 337(22):1576-83. DOI: 10.1056/NEJM199711273372202. View

5.
Kuck K, Cappato R, Siebels J, Ruppel R . Randomized comparison of antiarrhythmic drug therapy with implantable defibrillators in patients resuscitated from cardiac arrest : the Cardiac Arrest Study Hamburg (CASH). Circulation. 2000; 102(7):748-54. DOI: 10.1161/01.cir.102.7.748. View