Enhanced Brain Levels of 8,12-iso-iPF2alpha-VI Differentiate AD from Frontotemporal Dementia

Overview

Journal Neurology

Specialty Neurology

Date 2003 Aug 27

PMID 12939420

Citations 34

Authors

Y Yao

V Zhukareva

S Sung

C M Clark

J Rokach

V M-Y Lee

J Q Trojanowski

D Pratico

Affiliations

Soon will be listed here.

Abstract

Objective: To quantify the isoprostane 8,12-iso-iPF2alpha-VI in brain tissues obtained from patients with AD, patients with frontotemporal dementia (FTD), and controls.

Background: Enhanced brain oxidative stress with secondary damage to cellular macromolecules may play a role in the pathogenesis of AD and FTD. The isoprostane 8,12-iso-iPF2alpha-VI is a specific and sensitive marker of in vivo lipid peroxidation and is increased in AD.

Methods: Levels of this isoprostane were determined by gas chromatography/negative ion chemical ionization mass spectrometry.

Results: Levels of 8,12-iso-iPF2alpha-VI were markedly elevated in both frontal and temporal cortex of AD brains compared to the corresponding areas of FTD and controls. No significant difference in brain 8,12-iso-iPF2alpha-VI levels for any regions considered was observed between FTD and controls.

Conclusions: Lipid peroxidation is a feature of AD, but not FTD. The generation of 8,12-iso-iPF(2alpha)-VI in the brain is not a general or final common pathway of neurodegeneration, but may be relatively specific for disease processes in AD and not FTD.

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