Neonatologists Are Using Much Less Dexamethasone
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Pediatrics
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Two historical cohorts (1993-1994 and 2001) of preterm infants ventilated for respiratory distress syndrome were compared. Dexamethasone administration fell from 22% to 6%. Chronic lung disease in survivors rose slightly from 13% to 17%, and mortality fell from 21% to 15% (other causes). The effect of restriction of dexamethasone use on chronic lung disease and mortality remains to be seen.
van de Loo M, van Kaam A, Offringa M, Doyle L, Cooper C, Onland W Cochrane Database Syst Rev. 2024; 4:CD013271.
PMID: 38597338 PMC: 11005325. DOI: 10.1002/14651858.CD013271.pub2.
Systemic corticosteroid regimens for prevention of bronchopulmonary dysplasia in preterm infants.
Onland W, van de Loo M, Offringa M, van Kaam A Cochrane Database Syst Rev. 2023; 3:CD010941.
PMID: 36912887 PMC: 10015219. DOI: 10.1002/14651858.CD010941.pub3.
Morris I, Goel N, Chakraborty M Eur J Pediatr. 2019; 178(8):1171-1184.
PMID: 31144162 PMC: 6647381. DOI: 10.1007/s00431-019-03398-5.
Systemic corticosteroid regimens for prevention of bronchopulmonary dysplasia in preterm infants.
Onland W, De Jaegere A, Offringa M, van Kaam A Cochrane Database Syst Rev. 2017; 1:CD010941.
PMID: 28141913 PMC: 6464844. DOI: 10.1002/14651858.CD010941.pub2.
Sze C, Lin Y, Lin Y, Hsieh T, Kuo Y, Lin C Mediators Inflamm. 2013; 2013:628094.
PMID: 23401645 PMC: 3557631. DOI: 10.1155/2013/628094.