Long-term Protective Immune Response Elicited by Vaccination with an Expression Genomic Library of Toxoplasma Gondii

Overview

Journal Infect Immun

Publisher American Society for Microbiology

Specialty Allergy & Immunology

Date 2003 Aug 23

PMID 12933894

Citations 3

Authors

Alberto Fachado

Alexandro Rodriguez

Judith Molina

Jaline C Silverio

Ana P M P Marino

Luzia M O Pinto

Sergio O Angel

Juan F Infante

Yara Traub-Cseko

Regina R Amendoeira

Joseli Lannes-Vieira

Affiliations

Soon will be listed here.

Abstract

Immunization of BALB/c mice with an expression genomic library of Toxoplasma gondii induces a Th1-type immune response, with recognition of several T. gondii proteins (21 to 117 kDa) and long-term protective immunity against a lethal challenge. These results support further investigations to achieve a multicomponent anti-T. gondii DNA vaccine.

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