Intracellular Survival of Streptococcus Pyogenes in Polymorphonuclear Cells Results in Increased Bacterial Virulence

Overview

Journal Infect Immun

Publisher American Society for Microbiology

Specialty Allergy & Immunology

Date 2003 Aug 23

PMID 12933887

Citations 30

Authors

Eva Medina

Manfred Rohde

Gursharan S Chhatwal

Affiliations

Soon will be listed here.

Abstract

It has recently been shown that survival within phagocytic cells constitutes an additional strategy used by Streptococcus pyogenes to evade the host defenses. Here we provide evidence that S. pyogenes can escape from the phagosome into the cytoplasm of phagocytic cells. Furthermore, intracellular bacteria seem to undergo phenotypic switching that results in much more virulent microorganisms.

Citing Articles

Inflammatory Response Genes' Polymorphism Associated with Risk of Rheumatic Heart Disease.

Sinitskaya A, Khutornaya M, Hryachkova O, Asanov M, Poddubnyak A, Ponasenko A J Pers Med. 2024; 14(7).

PMID: 39064007 PMC: 11278136. DOI: 10.3390/jpm14070753.

Bacterial cholesterol-dependent cytolysins and their interaction with the human immune response.

Sanford T, Tweten R, Abrahamsen H Curr Opin Infect Dis. 2024; 37(3):164-169.

PMID: 38527455 PMC: 11042984. DOI: 10.1097/QCO.0000000000001010.

Synthetic mRNA delivered to human cells leads to expression of Cpl-1 bacteriophage-endolysin with activity against .

Jansson M, Nguyen D, Mikkat S, Warnke C, Janssen M, Warnke P Mol Ther Nucleic Acids. 2024; 35(1):102145.

PMID: 38435119 PMC: 10907214. DOI: 10.1016/j.omtn.2024.102145.

The tellurite resistance gene cluster of pathogenic bacteria and its effect on oxidative stress response.

Vavrova S, Grones J, Soltys K, Celec P, Turna J Folia Microbiol (Praha). 2024; 69(2):433-444.

PMID: 38261148 PMC: 11003894. DOI: 10.1007/s12223-024-01133-8.

Streptococcus 98.1 variants activate inflammatory caspases in human neutrophils.

Williams J, Sluyter R, Sanderson-Smith M Virulence. 2023; 14(1):2264090.

PMID: 37830540 PMC: 10578187. DOI: 10.1080/21505594.2023.2264090.

References

Efstratiou A . Group A streptococci in the 1990s. J Antimicrob Chemother. 2000; 45 Suppl:3-12. DOI: 10.1093/jac/45.suppl_1.3. View

Limbago B, Penumalli V, Weinrick B, Scott J . Role of streptolysin O in a mouse model of invasive group A streptococcal disease. Infect Immun. 2000; 68(11):6384-90. PMC: 97723. DOI: 10.1128/IAI.68.11.6384-6390.2000. View

Ravins M, Jaffe J, Hanski E, Shetzigovski I, Natanson-Yaron S, Moses A . Characterization of a mouse-passaged, highly encapsulated variant of group A streptococcus in in vitro and in vivo studies. J Infect Dis. 2000; 182(6):1702-11. DOI: 10.1086/317635. View

Engleberg N, Heath A, Miller A, Rivera C, DiRita V . Spontaneous mutations in the CsrRS two-component regulatory system of Streptococcus pyogenes result in enhanced virulence in a murine model of skin and soft tissue infection. J Infect Dis. 2001; 183(7):1043-54. DOI: 10.1086/319291. View

Medina E, Goldmann O, Rohde M, Lengeling A, Chhatwal G, Chhatwals G . Genetic control of susceptibility to group A streptococcal infection in mice. J Infect Dis. 2001; 184(7):846-52. DOI: 10.1086/323292. View

Lei B, DeLeo F, Hoe N, Graham M, Mackie S, Cole R . Evasion of human innate and acquired immunity by a bacterial homolog of CD11b that inhibits opsonophagocytosis. Nat Med. 2001; 7(12):1298-305. DOI: 10.1038/nm1201-1298. View

Betschel S, Borgia S, Barg N, Low D, de Azavedo J . Reduced virulence of group A streptococcal Tn916 mutants that do not produce streptolysin S. Infect Immun. 1998; 66(4):1671-9. PMC: 108104. DOI: 10.1128/IAI.66.4.1671-1679.1998. View

Medina E, Goldmann O, Toppel A, Chhatwal G . Survival of Streptococcus pyogenes within host phagocytic cells: a pathogenic mechanism for persistence and systemic invasion. J Infect Dis. 2003; 187(4):597-603. DOI: 10.1086/373998. View

Goldmann O, Chhatwal G, Medina E . Immune mechanisms underlying host susceptibility to infection with group A streptococci. J Infect Dis. 2003; 187(5):854-61. DOI: 10.1086/368390. View

10.

Fischetti V . Streptococcal M protein: molecular design and biological behavior. Clin Microbiol Rev. 1989; 2(3):285-314. PMC: 358122. DOI: 10.1128/CMR.2.3.285. View

11.

Cossart P, Vicente M, Mengaud J, Baquero F, Perez-Diaz J, Berche P . Listeriolysin O is essential for virulence of Listeria monocytogenes: direct evidence obtained by gene complementation. Infect Immun. 1989; 57(11):3629-36. PMC: 259877. DOI: 10.1128/iai.57.11.3629-3636.1989. View

12.

Wessels M, Moses A, Goldberg J, DiCesare T . Hyaluronic acid capsule is a virulence factor for mucoid group A streptococci. Proc Natl Acad Sci U S A. 1991; 88(19):8317-21. PMC: 52499. DOI: 10.1073/pnas.88.19.8317. View

13.

Raeder R, Boyle M . Association of type II immunoglobulin G-binding protein expression and survival of group A streptococci in human blood. Infect Immun. 1993; 61(9):3696-702. PMC: 281066. DOI: 10.1128/iai.61.9.3696-3702.1993. View

14.

Voyich J, Sturdevant D, Braughton K, Kobayashi S, Lei B, Virtaneva K . Genome-wide protective response used by group A Streptococcus to evade destruction by human polymorphonuclear leukocytes. Proc Natl Acad Sci U S A. 2003; 100(4):1996-2001. PMC: 149947. DOI: 10.1073/pnas.0337370100. View