Molecular Phylogeny Within Type I Cytokines and Their Cognate Receptors

Overview

Journal Immunity

Publisher Cell Press

Specialty Allergy & Immunology

Date 2003 Aug 23

PMID 12932349

Citations 91

Authors

Jean-Louis Boulay

John J OShea

William E Paul

Affiliations

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Abstract

Type I helical cytokines are ligands for receptors structurally related by a common sequence signature. Here we analyze the 27 ligands and 34 human type I cytokine receptor encoded by the human genome. We compare these to ligands and receptors found in mouse and insects. We describe their structural relatedness to one another and discuss the evolution of these gene families.

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