Sickle Cell Crisis and Endothelin Antagonists

Overview

Journal Crit Care Nurs Q

Specialties Critical Care
Nursing

Date 2003 Aug 22

PMID 12930038

Citations 4

Authors

Allan D Angerio

Nicole D Lee

Affiliations

Soon will be listed here.

Abstract

Sickle cell crisis may be more complex than a vaso-occlusive event in response to hypoxia. Endothelin-1 (ET-1) is a potent vasoconstrictor and mitogen secreted in response to hypoxia. ET-1 contributes to the vaso-occlusion and inflammation in sickle cell crisis. ET-1 antagonists may be useful in the prevention and treatment of crisis.

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