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Surfactin/iturin A Interactions May Explain the Synergistic Effect of Surfactin on the Biological Properties of Iturin A

Overview
Journal Biochimie
Specialty Biochemistry
Date 1992 Dec 1
PMID 1292612
Citations 42
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Abstract

Iturin A and surfactin are two lipopeptides extracted from a same strain of Bacillus subtilis. Iturin A possesses antibiotic and antifungal activities and surfactin is a strong surfactant. The presence of surfactin, at a concentration at which, alone, it is inactive, increases to a very large extent the haemolysis percent induced by iturin A. This synergistic effect seems to be in relation with interactions between iturin A and surfactin. Iturin A adsorbs to and penetrates into surfactin monolayers. Iturin A and surfactin are miscible and interact specifically in mixed monolayers.

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