Coxsackievirus Replication and the Cell Cycle: a Potential Regulatory Mechanism for Viral Persistence/latency

Overview

Journal Med Microbiol Immunol

Specialty Allergy & Immunology

Date 2003 Aug 20

PMID 12925877

Citations 17

Authors

Ralph Feuer

Ignacio Mena

Robb R Pagarigan

Daniel E Hassett

J Lindsay Whitton

Affiliations

Soon will be listed here.

Abstract

Coxsackieviruses (CV) are characterized by their ability to cause cytopathic effects in tissue culture and by their capacity to initiate acute disease by inducing apoptosis within targeted organs in vivo. These viruses are considered highly cytolytic, but can establish persistence/latency in susceptible cells, indicating that a regulatory mechanism may exist to shut off viral protein synthesis and replication under certain situations. The persistence of coxsackieviral RNA is of particular medical interest due to its association with chronic human diseases such as dilated cardiomyopathy and chronic inflammatory myopathy. Here, we discuss the potential mechanisms regulating coxsackievirus replication, and the ability of viral RNA to remain in an apparent latent state within quiescent cells.

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References

Zhang J, Silvestri N, Whitton J, Hassett D . Neonates mount robust and protective adult-like CD8(+)-T-cell responses to DNA vaccines. J Virol. 2002; 76(23):11911-9. PMC: 136875. DOI: 10.1128/jvi.76.23.11911-11919.2002. View

Li Y, Peng T, Yang Y, Niu C, Archard L, Zhang H . High prevalence of enteroviral genomic sequences in myocardium from cases of endemic cardiomyopathy (Keshan disease) in China. Heart. 2000; 83(6):696-701. PMC: 1760852. DOI: 10.1136/heart.83.6.696. View

Kim K, HUFNAGEL G, Chapman N, Tracy S . The group B coxsackieviruses and myocarditis. Rev Med Virol. 2001; 11(6):355-68. DOI: 10.1002/rmv.326. View

Opavsky M, Martino T, Rabinovitch M, Penninger J, Richardson C, Petric M . Enhanced ERK-1/2 activation in mice susceptible to coxsackievirus-induced myocarditis. J Clin Invest. 2002; 109(12):1561-9. PMC: 151008. DOI: 10.1172/JCI13971. View

Henke A, Huber S, Stelzner A, Whitton J . The role of CD8+ T lymphocytes in coxsackievirus B3-induced myocarditis. J Virol. 1995; 69(11):6720-8. PMC: 189582. DOI: 10.1128/JVI.69.11.6720-6728.1995. View

Dalakas M . New neuromuscular symptoms in patients with old poliomyelitis: a three-year follow-up study. Eur Neurol. 1986; 25(5):381-7. DOI: 10.1159/000116038. View

Archard L, Khan M, Soteriou B, Zhang H, Why H, Robinson N . Characterization of Coxsackie B virus RNA in myocardium from patients with dilated cardiomyopathy by nucleotide sequencing of reverse transcription-nested polymerase chain reaction products. Hum Pathol. 1998; 29(6):578-84. DOI: 10.1016/s0046-8177(98)80006-3. View

Wessely R, Henke A, Zell R, Kandolf R, Knowlton K . Low-level expression of a mutant coxsackieviral cDNA induces a myocytopathic effect in culture: an approach to the study of enteroviral persistence in cardiac myocytes. Circulation. 1998; 98(5):450-7. DOI: 10.1161/01.cir.98.5.450. View

Pyronnet S, Pradayrol L, Sonenberg N . A cell cycle-dependent internal ribosome entry site. Mol Cell. 2000; 5(4):607-16. DOI: 10.1016/s1097-2765(00)80240-3. View

10.

Dalakas M . New neuromuscular symptoms after old polio ("the post-polio syndrome"): clinical studies and pathogenetic mechanisms. Birth Defects Orig Artic Ser. 1987; 23(4):241-64. View

11.

Wessely R, Klingel K, Santana L, Dalton N, Hongo M, Lederer W . Transgenic expression of replication-restricted enteroviral genomes in heart muscle induces defective excitation-contraction coupling and dilated cardiomyopathy. J Clin Invest. 1998; 102(7):1444-53. PMC: 508992. DOI: 10.1172/JCI1972. View

12.

Destombes J, Couderc T, Thiesson D, Girard S, Wilt S, Blondel B . Persistent poliovirus infection in mouse motoneurons. J Virol. 1997; 71(2):1621-8. PMC: 191220. DOI: 10.1128/JVI.71.2.1621-1628.1997. View

13.

Klingel K, Rieger P, Mall G, Selinka H, Huber M, Kandolf R . Visualization of enteroviral replication in myocardial tissue by ultrastructural in situ hybridization: identification of target cells and cytopathic effects. Lab Invest. 1998; 78(10):1227-37. View

14.

Tam P, Schmidt A, Ytterberg S, Messner R . Duration of virus persistence and its relationship to inflammation in the chronic phase of coxsackievirus B1-induced murine polymyositis. J Lab Clin Med. 1994; 123(3):346-56. View

15.

Hassett D, Zhang J, Slifka M, Whitton J . Immune responses following neonatal DNA vaccination are long-lived, abundant, and qualitatively similar to those induced by conventional immunization. J Virol. 2000; 74(6):2620-7. PMC: 111750. DOI: 10.1128/jvi.74.6.2620-2627.2000. View

16.

Gage F . Mammalian neural stem cells. Science. 2000; 287(5457):1433-8. DOI: 10.1126/science.287.5457.1433. View

17.

Dalakas M, Elder G, Hallett M, Ravits J, Baker M, Papadopoulos N . A long-term follow-up study of patients with post-poliomyelitis neuromuscular symptoms. N Engl J Med. 1986; 314(15):959-63. DOI: 10.1056/NEJM198604103141505. View

18.

Brodsky VYa , Sarkisov D, Arefyeva A, Panova N . DNA and protein relations in cardiomyocytes. Growth reserve in cardiac muscle. Eur J Histochem. 1993; 37(3):199-206. View

19.

Estes M, RORKE L . Liquefactive necrosis in Coxsackie B encephalitis. Arch Pathol Lab Med. 1986; 110(11):1090-2. View

20.

Modlin J, Rotbart H . Group B coxsackie disease in children. Curr Top Microbiol Immunol. 1997; 223:53-80. DOI: 10.1007/978-3-642-60687-8_4. View