Narrow-band Ultraviolet B Treatment for Vitiligo, Pruritus, and Inflammatory Dermatoses
Overview
Affiliations
Background: Narrow-band ultraviolet B (NB-UVB) therapy has been used successfully for the treatment of inflammatory and pigmentary skin disorders including atopic dermatitis, psoriasis, mycosis fungoides, polymorphous light eruption, and vitiligo.
Methods: This is a retrospective review of the treatment outcomes of 117 consecutive patients with vitiligo, pruritus, and other inflammatory dermatoses, excluding those with psoriasis and CTCL, who were treated with NB-UVB between 1998 and 2001 at our institution.
Results: Approximately 80% of all patients showed improvement in their condition. NB-UVB phototherapy was well tolerated, with no serious adverse effects. In patients with vitiligo, 6.4% had an abnormal thyroid-stimulating hormone level and 6.5% had anemia.
Conclusion: NB-UVB may be considered as a viable therapeutic option in the treatment of vitiligo, pruritus, and other inflammatory dermatoses. Long-term adverse effects and cost-benefit analysis of NB-UVB therapy compared to other treatment modalities remain to be determined.
Current Status of Cell-Based Therapies for Vitiligo.
Domaszewska-Szostek A, Polak A, Slupecka-Ziemilska M, Krzyzanowska M, Puzianowska-Kuznicka M Int J Mol Sci. 2023; 24(4).
PMID: 36834766 PMC: 9964504. DOI: 10.3390/ijms24043357.
Narrowband Ultraviolet B Radiation for Lichen Planus: Long-term Follow-up of 192 Patients.
Dawood M, Sizopoulou C, Greenberger S, Barzilai A, Pavlotsky F J Clin Aesthet Dermatol. 2022; 15(4):31-35.
PMID: 35465030 PMC: 9017671.
Khojah H, Alharbi A, Alshaeri A, Alahmadi Y, Elbadawy H J Taibah Univ Med Sci. 2021; 16(6):843-848.
PMID: 34899128 PMC: 8626815. DOI: 10.1016/j.jtumed.2021.04.012.
Mittal A, Kumar M, Gopishankar N, Kumar P, Verma A Sci Rep. 2021; 11(1):684.
PMID: 33436878 PMC: 7804282. DOI: 10.1038/s41598-020-80115-5.
Pruritus: Progress toward Pathogenesis and Treatment.
Song J, Xian D, Yang L, Xiong X, Lai R, Zhong J Biomed Res Int. 2018; 2018:9625936.
PMID: 29850592 PMC: 5925168. DOI: 10.1155/2018/9625936.