Usefulness of [123I]metaiodobenzylguanidine ([123I]MIBG) Myocardial Scintigraphy in Differentiating Between Alzheimer's Disease and Dementia with Lewy Bodies

Overview

Journal Intern Med

Specialty General Medicine

Date 2003 Aug 20

PMID 12924492

Citations 6

Authors

Takashi Oide

Takahiko Tokuda

Mitsuhiro Momose

Kazuhiro Oguchi

Akinori Nakamura

Shinji Ohara

Shu-Ichi Ikeda

Affiliations

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Abstract

Objective: To confirm the clinical usefulness of [123I] metaiodobenzylguanidine ([123I]MIBG) myocardial scintigraphy in the antemortem differential diagnosis between patients with Alzheimer's disease (AD) and those with dementia with Lewy bodies (DLB).

Patients And Methods: We compared cardiac [123I] MIBG uptake in 10 patients with AD with that in 10 patients with DLB. We selected the patients with AD or DLB by using stringent diagnostic criteria that combined commonly used clinical criteria with tau protein levels in cerebrospinal fluid and radiographical examinations.

Results: The heart to mediastinum ratio of [123I]MIBG uptake in all the patients with DLB was significantly lower than that in the patients with AD (p<0.01).

Conclusion: This study confirms that [123I]MIBG myocardial scintigraphy is useful in the antemortem differential diagnosis of AD and DLB.

Citing Articles

Uniformity of cardiac I-MIBG uptake on SPECT images in older adults with normal cognition and patients with dementia.

Roberts G, Lloyd J, Jefferson E, Kane J, Durcan R, Lawley S J Nucl Cardiol. 2019; 28(5):2151-2163.

PMID: 31820410 PMC: 8648658. DOI: 10.1007/s12350-019-01977-5.

Utility of the combination of DAT SPECT and MIBG myocardial scintigraphy in differentiating dementia with Lewy bodies from Alzheimer's disease.

Shimizu S, Hirao K, Kanetaka H, Namioka N, Hatanaka H, Hirose D Eur J Nucl Med Mol Imaging. 2015; 43(1):184-192.

PMID: 26233438 PMC: 4679785. DOI: 10.1007/s00259-015-3146-y.

(123)I-Metaiodobenzylguanidine Myocardial Scintigraphy in Lewy Body-Related Disorders: A Literature Review.

Chung E, Kim S J Mov Disord. 2015; 8(2):55-66.

PMID: 26090077 PMC: 4460541. DOI: 10.14802/jmd.15015.

Diagnostic value of MIBG cardiac scintigraphy for differential dementia diagnosis.

Slaets S, Van Acker F, Versijpt J, Hauth L, Goeman J, Martin J Int J Geriatr Psychiatry. 2014; 30(8):864-9.

PMID: 25363642 PMC: 4657469. DOI: 10.1002/gps.4229.

Cardiac (123)I-metaiodobenzylguanidine imaging allows early identification of dementia with Lewy bodies during life.

Estorch M, Camacho V, Paredes P, Rivera E, Rodriguez-Revuelto A, Flotats A Eur J Nucl Med Mol Imaging. 2008; 35(9):1636-41.

PMID: 18509631 DOI: 10.1007/s00259-008-0828-8.