The Chiari II Malformation: Cause and Impact

Overview

Journal Childs Nerv Syst

Specialty Pediatrics

Date 2003 Aug 16

PMID 12920543

Citations 56

Authors

David G McLone

Mark S Dias

Affiliations

Soon will be listed here.

Abstract

Introduction: It is the Chiari II malformation and its effects that determine the quality of life of the individual born with spina bifida.

Discussion: The cause of this malformation has been a source of debate for many years. Understanding the cause enables strategies for the management of problems created by this malformation to be developed. An open neural tube defect allows fluid to escape from the cranial vesicles, altering the intracranial environment and leads to all of the brain changes seen in the Chiari II malformation. Decompression of the intracranial vesicles causes overcrowding, decrease in the size of the third ventricle, and changes in the fetal skull. It also permanently links the intracranial ventricular system to the spinal cord central canal.

Citing Articles

Comprehensive assessment of supratentorial and infratentorial volumes in infants with myelomeningocele with and without Chiari malformation type II.

Hashimoto H, Shimada M, Takemoto O, Chiba Y Neuroradiology. 2024; .

PMID: 39627608 DOI: 10.1007/s00234-024-03514-9.

Arnold-Chiari Malformations in Pediatric Patients After Fetal Surgery for Meningomyelocele.

Kohutkova M, Horn F J Clin Med. 2024; 13(22).

PMID: 39597865 PMC: 11595094. DOI: 10.3390/jcm13226721.

Regression of Chiari malformation type 2 following early postnatal meningomyelocele repair-a retrospective observation from an institutional series of patients.

Fric R, Beyer M, Due-Tonnessen B Childs Nerv Syst. 2024; 40(11):3641-3646.

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Revisiting the Pathophysiology of Intracranial Hemorrhage in Fetuses with Chiari II Malformation: Novel Imaging Biomarkers of Disease Severity?.

Shi H, Prayer D, Kienast P, Khalaveh F, Tischer J, Binder J AJNR Am J Neuroradiol. 2024; 45(10):1562-1569.

PMID: 38719608 PMC: 11449001. DOI: 10.3174/ajnr.A8331.

Myelomeningocele: Long-Term Neurosurgical Management.

Marcati E, Meccariello G, Mastino L, Picano M, Giorgi P, Talamonti G Adv Tech Stand Neurosurg. 2024; 49:95-122.

PMID: 38700682 DOI: 10.1007/978-3-031-42398-7_6.

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