Corticothalamic Modulation During Absence Seizures in Rats: a Functional MRI Assessment

Overview

Journal Epilepsia

Specialty Neurology

Date 2003 Aug 16

PMID 12919383

Citations 39

Authors

Jeffrey R Tenney

Timothy Q Duong

Jean A King

Reinhold Ludwig

Craig F Ferris

Affiliations

Soon will be listed here.

Abstract

Purpose: Functional magnetic resonance imaging (fMRI) was used to identify areas of brain activation during absence seizures in an awake animal model.

Methods: Blood-oxygenation-level-dependent (BOLD) fMRI in the brain was measured by using T2*-weighted echo planar imaging at 4.7 Tesla. BOLD imaging was performed before, during, and after absence seizure induction by using gamma-butyrolactone (GBL; 200 mg/kg, intraperitoneal).

Results: The corticothalamic circuitry, critical for spike-wave discharge (SWD) formation in absence seizure, showed robust BOLD signal changes after GBL administration, consistent with EEG recordings in the same animals. Predominantly positive BOLD changes occurred in the thalamus. Sensory and parietal cortices showed mixed positive and negative BOLD changes, whereas temporal and motor cortices showed only negative BOLD changes.

Conclusions: With the BOLD fMRI technique, we demonstrated signal changes in brain areas that have been shown, with electrophysiology experiments, to be important for generating and maintaining the SWDs that characterize absence seizures. These results corroborate previous findings from lesion and electrophysiological experiments and show the technical feasibility of noninvasively imaging absence seizures in fully conscious rodents.

Citing Articles

Palmitoylethanolamide causes dose-dependent changes in brain function and the lipidome.

Balaji S, Woodward T, Richter E, Chang A, Otiz R, Kulkarni P Front Neurosci. 2024; 18:1506352.

PMID: 39664446 PMC: 11631868. DOI: 10.3389/fnins.2024.1506352.

Wachsmuth L, Hebbelmann L, Prade J, Kohnert L, Lambers H, Luttjohann A Front Neurol. 2024; 15:1355862.

PMID: 38529038 PMC: 10961455. DOI: 10.3389/fneur.2024.1355862.

Where do we stand on fMRI in awake mice?.

Mandino F, Vujic S, Grandjean J, Lake E Cereb Cortex. 2023; 34(1).

PMID: 38100331 PMC: 10793583. DOI: 10.1093/cercor/bhad478.

The impact of vasomotion on analysis of rodent fMRI data.

Lambers H, Wachsmuth L, Lippe C, Faber C Front Neurosci. 2023; 17:1064000.

PMID: 36908777 PMC: 9998505. DOI: 10.3389/fnins.2023.1064000.

Applications in Awake Animal Magnetic Resonance Imaging.

Ferris C Front Neurosci. 2022; 16:854377.

PMID: 35450017 PMC: 9017993. DOI: 10.3389/fnins.2022.854377.

References

Zhang Z, Andersen A, Avison M, Gerhardt G, Gash D . Functional MRI of apomorphine activation of the basal ganglia in awake rhesus monkeys. Brain Res. 2000; 852(2):290-6. DOI: 10.1016/s0006-8993(99)02243-x. View

Yeni S, Kabasakal L, Yalcinkaya C, Nisli C, Dervent A . Ictal and interictal SPECT findings in childhood absence epilepsy. Seizure. 2000; 9(4):265-9. DOI: 10.1053/seiz.2000.0400. View

Avanzini G, Panzica F, de Curtis M . The role of the thalamus in vigilance and epileptogenic mechanisms. Clin Neurophysiol. 2000; 111 Suppl 2:S19-26. DOI: 10.1016/s1388-2457(00)00398-9. View

Iannetti P, Spalice A, De Luca P, Boemi S, Festa A, Maini C . Ictal single photon emission computed tomography in absence seizures: apparent implication of different neuronal mechanisms. J Child Neurol. 2001; 16(5):339-44. DOI: 10.1177/088307380101600506. View

Dubowitz D, Chen D, Atkinson D, Scadeng M, Martinez A, Andersen M . Direct comparison of visual cortex activation in human and non-human primates using functional magnetic resonance imaging. J Neurosci Methods. 2001; 107(1-2):71-80. DOI: 10.1016/s0165-0270(01)00353-3. View

Ferris C, Snowdon C, King J, Duong T, Ziegler T, Ugurbil K . Functional imaging of brain activity in conscious monkeys responding to sexually arousing cues. Neuroreport. 2001; 12(10):2231-6. DOI: 10.1097/00001756-200107200-00037. View

Logothetis N, Pauls J, Augath M, Trinath T, Oeltermann A . Neurophysiological investigation of the basis of the fMRI signal. Nature. 2001; 412(6843):150-7. DOI: 10.1038/35084005. View

Zhang Z, Andersen A, Grondin R, Barber T, Avison R, Gerhardt G . Pharmacological MRI mapping of age-associated changes in basal ganglia circuitry of awake rhesus monkeys. Neuroimage. 2001; 14(5):1159-67. DOI: 10.1006/nimg.2001.0902. View

Meeren H, Pijn J, van Luijtelaar E, Coenen A, Lopes da Silva F . Cortical focus drives widespread corticothalamic networks during spontaneous absence seizures in rats. J Neurosci. 2002; 22(4):1480-95. PMC: 6757554. View

10.

Richards C . On the mechanism of barbiturate anaesthesia. J Physiol. 1972; 227(3):749-67. PMC: 1331285. DOI: 10.1113/jphysiol.1972.sp010057. View

11.

Richards C . On the mechanism of halothane anaesthesia. J Physiol. 1973; 233(2):439-56. PMC: 1350575. DOI: 10.1113/jphysiol.1973.sp010316. View

12.

Richards C, White A . The actions of volatile anaesthetics on synaptic transmission in the dentate gyrus. J Physiol. 1975; 252(1):241-57. PMC: 1348476. DOI: 10.1113/jphysiol.1975.sp011142. View

13.

Wolfson L, Sakurada O, Sokoloff L . Effects of gamma-butyrolactone on local cerebral glucose utilization in the rat. J Neurochem. 1977; 29(5):777-83. DOI: 10.1111/j.1471-4159.1977.tb10718.x. View

14.

Bearden L, Snead O, Healey C, Pegram G . Antagonism of gamma-hydroxybutyric acid-induced frequency shifts in the cortical EEG of rats by dipropylacetate. Electroencephalogr Clin Neurophysiol. 1980; 49(1-2):181-3. DOI: 10.1016/0013-4694(80)90365-x. View

15.

Engel Jr J, Lubens P, Kuhl D, Phelps M . Local cerebral metabolic rate for glucose during petit mal absences. Ann Neurol. 1985; 17(2):121-8. DOI: 10.1002/ana.410170204. View

16.

Theodore W, Brooks R, Margolin R, Patronas N, Sato S, Porter R . Positron emission tomography in generalized seizures. Neurology. 1985; 35(5):684-90. DOI: 10.1212/wnl.35.5.684. View

17.

Richards C, Strupinski K . An analysis of the action of pentobarbitone on the excitatory postsynaptic potentials and membrane properties of neurones in the guinea-pig olfactory cortex. Br J Pharmacol. 1986; 89(2):321-5. PMC: 1917017. DOI: 10.1111/j.1476-5381.1986.tb10263.x. View

18.

Ochs R, Gloor P, Tyler J, Wolfson T, Worsley K, Andermann F . Effect of generalized spike-and-wave discharge on glucose metabolism measured by positron emission tomography. Ann Neurol. 1987; 21(5):458-64. DOI: 10.1002/ana.410210508. View

19.

Snead 3rd O . gamma-Hydroxybutyrate model of generalized absence seizures: further characterization and comparison with other absence models. Epilepsia. 1988; 29(4):361-8. DOI: 10.1111/j.1528-1157.1988.tb03732.x. View

20.

El-Beheiry H, Puil E . Anaesthetic depression of excitatory synaptic transmission in neocortex. Exp Brain Res. 1989; 77(1):87-93. DOI: 10.1007/BF00250570. View