Spontaneous Activity of Morphologically Identified Ganglion Cells in the Developing Ferret Retina

Overview

Journal J Neurosci

Specialty Neurology

Date 2003 Aug 15

PMID 12917368

Citations 9

Authors

Lauren C Liets

Bruno A Olshausen

Guo-Yong Wang

Leo M Chalupa

Affiliations

Soon will be listed here.

Abstract

Whole-cell patch-clamp recordings were made from morphologically identified ganglion cells in the intact retina of developing ferrets. As early as 3 d after birth, all ganglion cells exhibited bursts of spontaneous activity, with the interval between bursts gradually decreasing with maturity. By 2 weeks after birth, ganglion cells could be morphologically differentiated into three major classes (alpha, beta, and gamma), and at this time each cell class was characterized by a distinct pattern of spontaneous activity. Dual patch-clamp recordings from pairs of neighboring cells revealed that cells of all morphological classes burst in a coordinated manner, regardless of cell type. These observations suggest that a common mechanism underlies the bursting patterns exhibited by all ganglion cell classes, and that class-specific firing patterns emerge coincident with retinal ganglion cell morphological differentiation.

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