[Studies on the Phenolic Acid Constituents from Chinese Medicine "sheng-ma", Rhizome of Cimicifuga Foetida L]
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Aim: To look for new active constituents from Chinese medicine "Sheng-ma", rhizome of Cimicifuga foetida L.
Methods: The compounds were separated and purified by chromatography on silica gel and Sephadex LH-20. Their structures were determined by spectral analysis and chemical reaction.
Results: Eight compounds were obtained and identified as cimicifugic acid (1), esculetin (2), caffeic acid methyl ester (3), 4-O-acetyl-caffeic acid (4), sinapic acid (5), caffeic acid (6), ferulic acid (7), isoferulic acid (8).
Conclusion: Compound 1 is a new compound, and compounds 2-7 were isolated from this plant for the first time.
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PMID: 38256067 PMC: 10816090. DOI: 10.3390/ijms25020989.
Bahetjan Y, Muhaxi M, Pang K, Kizaibek M, Tang H, Sefidkon F Molecules. 2023; 28(13).
PMID: 37446853 PMC: 10343754. DOI: 10.3390/molecules28135191.
Chen H, Olatunji O, Zhou Y J Nat Med. 2016; 70(3):610-9.
PMID: 26972100 DOI: 10.1007/s11418-016-0984-2.
Phytochemistry of cimicifugic acids and associated bases in Cimicifuga racemosa root extracts.
Godecke T, Nikolic D, Lankin D, Chen S, Powell S, Dietz B Phytochem Anal. 2009; 20(2):120-33.
PMID: 19140115 PMC: 2715282. DOI: 10.1002/pca.1106.