Conjugated Linoleic Acid (CLA) Inhibits Fatty Acid Synthetase Activity in Vitro

Overview

Journal Biosci Biotechnol Biochem

Publisher Oxford University Press

Specialties Biochemistry
Biotechnology

Date 2003 Aug 13

PMID 12913306

Citations 7

Authors

Hirosuke Oku

Sawitree Wongtangtintharn

Hironori Iwasaki

Takayoshi Toda

Affiliations

Soon will be listed here.

Abstract

This paper describes the in vitro effect of conjugated linoleic acid (CLA) on fatty acid biosynthesis. Among the rat liver enzymes involved in fatty acid biosynthesis, fatty acid synthetase (FAS) showed the largest activity fluctuation with the types of fatty acids. Of the fatty acids, CLA was the most potent inhibitor of FAS, and the 9c, 11t-rather than the 10t, 12c-isomer showed greater inhibition. CLA also significantly lowered the incorporation of [14C]-acetate into phospholipid in breast cancer cells, supporting the view that CLA inhibits fatty acid biosynthesis through the interaction with FAS.

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