Greedy Method for Inferring Tandem Duplication History

Overview

Journal Bioinformatics

Publisher Oxford University Press

Specialty Biology

Date 2003 Aug 13

PMID 12912830

Citations 7

Authors

Louxin Zhang

Bin Ma

Lusheng Wang

Ying Xu

Affiliations

Soon will be listed here.

Abstract

Motivation: Genome analysis suggests that tandem duplication is an important mode of evolutionary novelty by permitting one copy of each gene to drift and potentially to acquire a new function. With more and more genomic sequences available, reconstructing duplication history has received extensive attention recently.

Results: An efficient method is presented for inferring the duplication history of tandemly repeated sequences based on the model proposed by Fitch (1977). We validate the method by using simulation results and real data sets of mucin genes, ZNF genes, and olfactory receptors genes. The agreement with conclusions drawn by other biological researchers strongly indicates that our method is efficient and robust.

Availability: The program is available by request.

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