Osteoarthritis

Overview

Journal Postgrad Med J

Publisher Oxford University Press

Specialty General Medicine

Date 2003 Aug 5

PMID 12897215

Citations 54

Authors

I Haq

E Murphy

J Dacre

Affiliations

Soon will be listed here.

Abstract

Osteoarthritis is a chronic degenerative disorder characterised by cartilage loss. It is extremely prevalent in society and is a major cause of disability. It is important to treat osteoarthritis effectively using a multidisciplinary approach tailored to the patient's needs. This paper reviews current thinking on the aetiology, pathogenesis, investigations, and management of osteoarthritis. The paper also discusses the challenges for developing good quality outcome measures for use in large scale multicentre clinical trials for new osteoarthritis treatments, especially disease modifying osteoarthritis drugs.

Citing Articles

Intra-articular Knee Neurofibroma in a Patient with Neurofibromatosis: A Case Report and Review of Literature.

Falconiero T, LaGreca M, Badragheh A, Jones N, Kester C J Orthop Case Rep. 2024; 14(10):140-145.

PMID: 39381300 PMC: 11458227. DOI: 10.13107/jocr.2024.v14.i10.4840.

Evaluation of efficacy and safety of glucosamine sulfate, chondroitin sulfate, and their combination regimen in the management of knee osteoarthritis: a systematic review and meta-analysis.

Rabade A, Viswanatha G, Nandakumar K, Kishore A Inflammopharmacology. 2024; 32(3):1759-1775.

PMID: 38581640 DOI: 10.1007/s10787-024-01460-9.

Alteration of Lower Limb Kinematics and Kinetics due to Bilateral Triple Arthrodesis.

Hejazi S, Herzog W, Rouhi G Arch Bone Jt Surg. 2023; 11(11):711-716.

PMID: 38058970 PMC: 10697195. DOI: 10.22038/ABJS.2023.68704.3246.

Association between ankle torque and performance-based tests, self-reported pain, and physical function in patients with knee osteoarthritis.

Carvalho C, Helena Goncalves G, Selistre L, Petrella M, Sato T, Serrao P Arch Rheumatol. 2023; 38(3):387-396.

PMID: 38046241 PMC: 10689021. DOI: 10.46497/ArchRheumatol.2023.9386.

Development of an automated optimal distance feature-based decision system for diagnosing knee osteoarthritis using segmented X-ray images.

Fatema K, Rony M, Azam S, Mukta M, Karim A, Hasan M Heliyon. 2023; 9(11):e21703.

PMID: 38027947 PMC: 10665756. DOI: 10.1016/j.heliyon.2023.e21703.

References

McAlindon T, LaValley M, Gulin J, Felson D . Glucosamine and chondroitin for treatment of osteoarthritis: a systematic quality assessment and meta-analysis. JAMA. 2000; 283(11):1469-75. DOI: 10.1001/jama.283.11.1469. View

Felson D, Zhang Y, Hannan M, Naimark A, Weissman B, Aliabadi P . The incidence and natural history of knee osteoarthritis in the elderly. The Framingham Osteoarthritis Study. Arthritis Rheum. 1995; 38(10):1500-5. DOI: 10.1002/art.1780381017. View

Disler D, Recht M, McCauley T . MR imaging of articular cartilage. Skeletal Radiol. 2000; 29(7):367-77. DOI: 10.1007/s002560000222. View

Messier S, Loeser R, Mitchell M, Valle G, Morgan T, Rejeski W . Exercise and weight loss in obese older adults with knee osteoarthritis: a preliminary study. J Am Geriatr Soc. 2000; 48(9):1062-72. DOI: 10.1111/j.1532-5415.2000.tb04781.x. View

Silverstein F, Faich G, Goldstein J, Simon L, Pincus T, WHELTON A . Gastrointestinal toxicity with celecoxib vs nonsteroidal anti-inflammatory drugs for osteoarthritis and rheumatoid arthritis: the CLASS study: A randomized controlled trial. Celecoxib Long-term Arthritis Safety Study. JAMA. 2000; 284(10):1247-55. DOI: 10.1001/jama.284.10.1247. View

. Recommendations for the medical management of osteoarthritis of the hip and knee: 2000 update. American College of Rheumatology Subcommittee on Osteoarthritis Guidelines. Arthritis Rheum. 2000; 43(9):1905-15. DOI: 10.1002/1529-0131(200009)43:9<1905::AID-ANR1>3.0.CO;2-P. View

Walker-Bone K, Javaid K, Arden N, Cooper C . Regular review: medical management of osteoarthritis. BMJ. 2000; 321(7266):936-40. PMC: 1118736. DOI: 10.1136/bmj.321.7266.936. View

Fernandes J, Martel-Pelletier J, Pelletier J . Gene therapy for osteoarthritis: new perspectives for the twenty-first century. Clin Orthop Relat Res. 2000; (379 Suppl):S262-72. View

Bombardier C, Laine L, Reicin A, Shapiro D, Burgos-Vargas R, Davis B . Comparison of upper gastrointestinal toxicity of rofecoxib and naproxen in patients with rheumatoid arthritis. VIGOR Study Group. N Engl J Med. 2000; 343(21):1520-8, 2 p following 1528. DOI: 10.1056/NEJM200011233432103. View

10.

Pendleton A, Arden N, Dougados M, Doherty M, Bannwarth B, Bijlsma J . EULAR recommendations for the management of knee osteoarthritis: report of a task force of the Standing Committee for International Clinical Studies Including Therapeutic Trials (ESCISIT). Ann Rheum Dis. 2000; 59(12):936-44. PMC: 1753053. DOI: 10.1136/ard.59.12.936. View

11.

Reginster J, Deroisy R, Rovati L, Lee R, Lejeune E, Bruyere O . Long-term effects of glucosamine sulphate on osteoarthritis progression: a randomised, placebo-controlled clinical trial. Lancet. 2001; 357(9252):251-6. DOI: 10.1016/S0140-6736(00)03610-2. View

12.

Brandt K, Bradley J . Should the initial drug be used to treat osteoarthritis pain be a nonsteroidal antiinflammatory drug?. J Rheumatol. 2001; 28(3):467-73. View

13.

Vignon E, Garnero P, Delmas P, Avouac B, Bettica P, Boers M . Recommendations for the registration of drugs used in the treatment of osteoarthritis: an update on biochemical markers. Osteoarthritis Cartilage. 2001; 9(4):289-93. DOI: 10.1053/joca.2000.0387. View

14.

Halbert J, Crotty M, Weller D, Ahern M, Silagy C . Primary care-based physical activity programs: effectiveness in sedentary older patients with osteoarthritis symptoms. Arthritis Rheum. 2001; 45(3):228-34. DOI: 10.1002/1529-0131(200106)45:3<228::AID-ART253>3.0.CO;2-2. View

15.

Angst F, Aeschlimann A, Steiner W, Stucki G . Responsiveness of the WOMAC osteoarthritis index as compared with the SF-36 in patients with osteoarthritis of the legs undergoing a comprehensive rehabilitation intervention. Ann Rheum Dis. 2001; 60(9):834-40. PMC: 1753825. View

16.

Brand C, Snaddon J, Bailey M, Cicuttini F . Vitamin E is ineffective for symptomatic relief of knee osteoarthritis: a six month double blind, randomised, placebo controlled study. Ann Rheum Dis. 2001; 60(10):946-9. PMC: 1753379. DOI: 10.1136/ard.60.10.946. View

17.

Ayral X . Injections in the treatment of osteoarthritis. Best Pract Res Clin Rheumatol. 2001; 15(4):609-26. DOI: 10.1053/berh.2001.0177. View

18.

Dougados M, Nguyen M, Berdah L, Mazieres B, Vignon E, Lequesne M . Evaluation of the structure-modifying effects of diacerein in hip osteoarthritis: ECHODIAH, a three-year, placebo-controlled trial. Evaluation of the Chondromodulating Effect of Diacerein in OA of the Hip. Arthritis Rheum. 2001; 44(11):2539-47. DOI: 10.1002/1529-0131(200111)44:11<2539::aid-art434>3.0.co;2-t. View

19.

Loughlin J . Genome studies and linkage in primary osteoarthritis. Rheum Dis Clin North Am. 2002; 28(1):95-109. DOI: 10.1016/s0889-857x(03)00071-1. View

20.

Hunter D, March L, Sambrook P . Knee osteoarthritis: the influence of environmental factors. Clin Exp Rheumatol. 2002; 20(1):93-100. View