The Emerging Role of Lysophosphatidic Acid in Cancer

Overview

Journal Nat Rev Cancer

Specialty Oncology

Date 2003 Aug 2

PMID 12894246

Citations 483

Authors

Gordon B Mills

Wouter H Moolenaar

Affiliations

Soon will be listed here.

Abstract

The bioactive phospholipid lysophosphatidic acid (LPA) stimulates cell proliferation, migration and survival by acting on its cognate G-protein-coupled receptors. Aberrant LPA production, receptor expression and signalling probably contribute to cancer initiation, progression and metastasis. The recent identification of ecto-enzymes that mediate the production and degradation of LPA, as well as the development of receptor-selective analogues, indicate mechanisms by which LPA production or action could be modulated for cancer therapy.

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