Clinical Aspects of Hepatosplenic Schistosomiasis: a Contrast with Cirrhosis

Overview

Journal Yale J Biol Med

Specialty Biology

Date 1975 Nov 1

PMID 128911

Citations 13

Authors

G REBOUCAS

Affiliations

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Abstract

The clinical picture of liver disease in endemic areas of Schistosomiasis mansoni differs in many ways from that observed in alcoholic and other types of cirrhosis. In hepatosplenic schistosomiasis there is predominance of the clinical manifestations of portal hypertension, e.g., bleeding esophageal varices, while ascites, jaundice, and hepatic precoma or coma are much less common. Ammonia tolerance is usually normal and helps explain the low mortality rate during bleeding. Of special interest is the observation of a high incidence of persistent hepatitis B surface antigenemia among patients with hepatosplenic schistosomiasis, suggesting increased susceptibility of such patients to the development of virus-induced chronic active hepatitis.

Citing Articles

Natural History of Hepatosplenic Schistosomiasis (HSS) Non-Cirrhotic Portal Hypertension (NCPH): Influence of Gastrointestinal Bleeding and Decompensation in Prognosis.

Veiga Z, Fernandes F, Guimaraes L, Piedade J, Pereira G Trop Med Infect Dis. 2023; 8(3).

PMID: 36977145 PMC: 10054624. DOI: 10.3390/tropicalmed8030145.

THE SPLENIC INDEX AS PREDICTOR OF BLEEDING AND VARICEAL RECURRENCE IN THE LATE FOLLOW-UP OF SCHISTOSOMOTIC PATIENTS AFTER EXCLUSIVE ENDOSCOPIC TREATMENT.

Borgheresi A, Colleoni R, Scalabrini M, Shigueoka D Arq Bras Cir Dig. 2022; 34(4):e1638.

PMID: 35107500 PMC: 8846378. DOI: 10.1590/0102-672020210002e1638.

Hepatic schistosomiasis, upper gastrointestinal bleeding, and health related quality of life measurements from the Albert Nile Basin.

Opio C, Kazibwe F, Rejani L, Kabatereine N, Ocama P J Patient Rep Outcomes. 2021; 5(1):112.

PMID: 34718894 PMC: 8557235. DOI: 10.1186/s41687-021-00389-9.

The cost-effectiveness of schistosomiasis screening and treatment among recently resettled refugees to Canada: an economic evaluation.

Webb J, Fabreau G, Spackman E, Vaughan S, McBrien K CMAJ Open. 2021; 9(1):E125-E133.

PMID: 33622765 PMC: 8034375. DOI: 10.9778/cmajo.20190057.

Praziquantel and Upper Gastrointestinal Bleeding in Hepatic Schistosomiasis: A Quasi-Experimental Study.

Opio C, Kazibwe F, Kabatereine N, Rejani L, Ocama P Drugs Real World Outcomes. 2020; 8(2):153-162.

PMID: 33367992 PMC: 8128957. DOI: 10.1007/s40801-020-00222-7.

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