Role of MAP Kinase in Tumor Progression and Invasion

Overview

Journal Cancer Metastasis Rev

Specialty Oncology

Date 2003 Jul 30

PMID 12884914

Citations 201

Authors

Kaladhar B Reddy

Sanaa M Nabha

Natasha Atanaskova

Affiliations

Soon will be listed here.

Abstract

Activation of the mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) pathway is a frequent event in tumorigenesis. MAPKs have been implicated in cell migration, proteinase-induction, regulation of apoptosis, and angiogenesis, events that are essential for successful completion of metastasis. In this review, we discuss the potential role that MAPKs play in metastasis by regulating cell migration, proteinase-induction and apoptosis.

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