Cinacalcet HCl: a Calcimimetic Agent for the Management of Primary and Secondary Hyperparathyroidism

Overview

Journal Expert Opin Investig Drugs

Specialty Pharmacology

Date 2003 Jul 29

PMID 12882626

Citations 4

Authors

Nora Franceschini

Melanie S Joy

Abhijit Kshirsagar

Affiliations

Soon will be listed here.

Abstract

Cinacalcet HCl (AMG 073) is an investigational oral calcimimetic drug currently being evaluated for the treatment of primary and secondary hyperparathyroidism (HPT). Calcimimetics bind to the calcium-sensing receptors of the parathyroid glands and lower the sensitivity for receptor activation by extracellular calcium, thereby diminishing parathyroid hormone release. Cinacalcet HCl has demonstrated efficacy in controlling the hypercalcaemia of severe primary HPT and in reducing parathyroid hormone levels in patients with secondary HPT. Asymptomatic dose-dependent hypocalcaemia has occurred in some clinical trials. This drug has a favourable pharmacokinetic profile compared to its precursors and will prove useful as an additional/alternative agent in patients with primary and secondary HPT.

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