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Cooperative Omega Loops in Cytochrome C: Role in Folding and Function

Overview
Journal J Mol Biol
Publisher Elsevier
Date 2003 Jul 24
PMID 12875833
Citations 52
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Abstract

Hydrogen exchange experiments under slow exchange conditions show that an omega loop in cytochrome c (residues 40-57) acts as a cooperative unfolding/refolding unit under native conditions. This unit behavior accounts for an initial step on the unfolding pathway, a final step in refolding, and a number of other structural, functional and evolutionary properties.

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