» Articles » PMID: 12872909

Neutral Effect of Recombination on Base Composition in Drosophila

Overview
Journal Genet Res
Specialty Genetics
Date 2003 Jul 23
PMID 12872909
Citations 43
Authors
Affiliations
Soon will be listed here.
Abstract

Recombination is thought to have various evolutionary effects on genome evolution. In this study, we investigated the relationship between the base composition and recombination rate in the Drosophila melanogaster genome. Because of a current debate about the accuracy of the estimates of recombination rate in Drosophila, we used eight different measures of recombination rate from recent work. We confirmed that the G + C content of large introns and flanking regions is positively correlated with recombination rate, suggesting that recombination has a neutral effect on base composition in Drosophila. We also confirmed that this neutral effect of recombination is the main determinant of the correlation between synonymous codon usage bias and recombination rate in Drosophila.

Citing Articles

Nucleotide composition affects codon usage toward the 3'-end.

Zahdeh F, Carmel L PLoS One. 2019; 14(12):e0225633.

PMID: 31800603 PMC: 6892556. DOI: 10.1371/journal.pone.0225633.


Large-Scale Comparative Analysis of Codon Models Accounting for Protein and Nucleotide Selection.

Davydov I, Salamin N, Robinson-Rechavi M Mol Biol Evol. 2019; 36(6):1316-1332.

PMID: 30847475 PMC: 6526913. DOI: 10.1093/molbev/msz048.


Genome-wide analysis of codon usage bias in four sequenced cotton species.

Wang L, Xing H, Yuan Y, Wang X, Saeed M, Tao J PLoS One. 2018; 13(3):e0194372.

PMID: 29584741 PMC: 5870960. DOI: 10.1371/journal.pone.0194372.


Evolutionary determinants of genome-wide nucleotide composition.

Long H, Sung W, Kucukyildirim S, Williams E, Miller S, Guo W Nat Ecol Evol. 2018; 2(2):237-240.

PMID: 29292397 PMC: 6855595. DOI: 10.1038/s41559-017-0425-y.


Fine-Scale Recombination Maps of Fungal Plant Pathogens Reveal Dynamic Recombination Landscapes and Intragenic Hotspots.

Stukenbrock E, Dutheil J Genetics. 2017; 208(3):1209-1229.

PMID: 29263029 PMC: 5844332. DOI: 10.1534/genetics.117.300502.