Structural Analogues of the Bimetallic Reaction Center in Acetyl CoA Synthase: a Ni--Ni Model with Bound CO

Overview

Journal J Am Chem Soc

Publisher American Chemical Society

Specialty Chemistry

Date 2003 Jul 17

PMID 12862445

Citations 18

Authors

Rachel C Linck

Cameron W Spahn

Thomas B Rauchfuss

Scott R Wilson

Affiliations

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Abstract

Models for the active site of the acetyl CoA synthase (ACS) were synthesized by attachment of Cu+ and Ni(0) to nickel diaminodithiolate (S2N2) and diamidodithiolate (S2N2') complexes. The Ni-Ni species form stable CO adducts, i.e., [{(CO)2Ni}{NiS2N2'}]2-, whereas the Cu-NiS2N2 and Cu-NiS2N2' models do not. These results provide supporting evidence for a biological role for reduced nickel in ACS.

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