E4orf3 is Necessary for Enhanced S-phase Replication of Cell Cycle-restricted Subgroup C Adenoviruses

Overview

Journal J Virol

Publisher American Society for Microbiology

Date 2003 Jul 15

PMID 12857931

Citations 18

Authors

Robin N Shepard

David A Ornelles

Affiliations

Soon will be listed here.

Abstract

E1B-55K-mutant or E4orf6-mutant adenoviruses replicate more effectively after infecting cells in S phase than after infecting cells in G(1). Enhanced S-phase replication of the E4orf6-mutant viruses requires the E4orf3 gene. This report demonstrates that the E4orf3 gene is also required for enhanced S-phase replication of the E1B-55K-mutant virus.

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