NQO1 C609T Polymorphism Associated with Esophageal Cancer and Gastric Cardiac Carcinoma in North China

Overview

Journal World J Gastroenterol

Publisher Baishideng Publishing Group

Specialty Gastroenterology

Date 2003 Jul 11

PMID 12854127

Citations 22

Authors

Jian-Hui Zhang

Yan Li

Rui Wang

Helen Geddert

Wei Guo

Deng-Gui Wen

Zhi-Feng Chen

Li-Zhen Wei

Gang Kuang

Ming He

Li-Wei Zhang

Ming-Li Wu

Shi-Jie Wang

Affiliations

Soon will be listed here.

Abstract

Aim: To investigate the association of the NQO1 (C609T) polymorphism with susceptibility to esophageal squamous cell carcinoma (ESCC) and gastric cardiac adenocarcinoma (GCA) in North China.

Methods: The NQO1 C609T genotypes were determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis in 317 cancer patients (193 ESCC and 124 GCA) and 165 unrelated healthy controls.

Results: The NQO1 C609T C/C, C/T and T/T genotype frequency among healthy controls was 31.5 %, 52.1 % and 16.4 % respectively. The NQO1 T/T genotype frequency among ESCC patients (25.9 %) was significantly higher than that among healthy controls (chi(2)=4.79, P=0.028). The NQO1 T/T genotype significantly increased the risk for developing ESCC compared with the combination of C/C and C/T genotypes, with an age, sex and smoking status adjusted odds ratio (OR) of 1.78 (1.04-2.98). This increased susceptibility was pronounced in ESCC patients with family histories of upper gastrointestinal cancers (UGIC) (adjusted OR=2.20, 95 % CI=1.18-3.98). Similarly, the susceptibility of the NQO1 T/T genotype to GCA development was also observed among patients with family histories of UGIC, with an adjusted odds ratio of 2.55 (95 % CI=1.21-5.23), whereas no difference in NQO1 genotype distribution was shown among patients without family histories of UGIC.

Conclusion: Determination of the NQO1 C609T genotype may be used as a stratification marker to predicate the individuals at high risk for developing ESCC and GCA in North China.

Citing Articles

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Akhtari F, Green A, Small G, Havener T, House J, Roell K PLoS Genet. 2021; 17(8):e1009732.

PMID: 34437536 PMC: 8439493. DOI: 10.1371/journal.pgen.1009732.

Joint effect of smoking and NQO1 C609T polymorphism on undifferentiated nasopharyngeal carcinoma risk in a North African population.

Moumad K, Khaali W, Benider A, Ayoub W, Hamdi-Cherif M, Boualga K Mol Genet Genomic Med. 2018; 6(6):933-940.

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The relationship between C609T and C-262Tgenetic polymorphisms and the risk of age-related cataracts.

Zarei N, Saadat I, Farvardin-Jahromi M Mol Biol Res Commun. 2016; 4(3):143-149.

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Genetic association of NQO1 609C>T polymorphism with risk of gastrointestinal cancer: evidence from case-control studies.

Liu H, Zhou S, Ma L, Yang J, Yang H Int J Clin Exp Med. 2015; 8(4):6046-52.

PMID: 26131202 PMC: 4484002.

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