Comparative Effects of Helium-oxygen and External Positive End-expiratory Pressure on Respiratory Mechanics, Gas Exchange, and Ventilation-perfusion Relationships in Mechanically Ventilated Patients with Chronic Obstructive Pulmonary Disease

Overview

Journal Intensive Care Med

Specialty Critical Care

Date 2003 Jul 10

PMID 12851764

Citations 5

Authors

Philippe Jolliet

Christine Watremez

Jean Roeseler

J C Ngengiyumva

Marc De Kock

Thierry Clerbaux

Didier Tassaux

Marc Reynaert

Bruno Detry

Giuseppe Liistro

Affiliations

Soon will be listed here.

Abstract

Objective: To compare the effects of He/O(2) and external PEEP (PEEPe) on intrinsic PEEP (PEEPi), respiratory mechanics, gas exchange, and ventilation/perfusion (V(A)/Q) in mechanically ventilated COPD patients.

Design And Setting: Prospective, interventional study in the intensive care unit of a university hospital.

Interventions: Ten intubated, sedated, paralyzed, mechanically ventilated COPD patients studied in the following conditions: (a) baseline settings made by clinician in charge, air/O(2), ZEEP; (b) He/O(2), ZEEP; (c) air/O(2), ZEEP; (d) air/O(2), PEEPe 80% of PEEPi. Measurements at each condition included V(A)/Q by the multiple inert gas elimination technique (MIGET).

Results: PEEPi and trapped gas volume were comparably reduced by He/O(2) (4.2+/-4 vs. 7.7+/-4 cmH(2)O and 98+/-82 vs. 217+/-124 ml, respectively) and PEEPe (4.4+/-1.3 vs. 7.8+/-3.6 cmH(2)O and 120+/-107 vs. 216+/-115 ml, respectively). He/O(2) reduced inspiratory and expiratory respiratory system resistance (15.5+/-4.4 vs. 20.7+/-6.9 and 19+/-9 vs. 28.8+/-15 cmH(2)O l(-1)s(-1), respectively) and plateau pressure (13+/-4 vs. 17+/-6 cmH(2)O). PEEPe increased airway pressures, including total PEEP, and elastance. PaO(2)/FIO(2) was slightly reduced by He/O(2) (225+/-83 vs. 245+/-82) without significant V(A)/Q change.

Conclusions: He/O(2) and PEEPe comparably reduced PEEPi and trapped gas volume. However, He/O(2) decreased airway resistance and intrathoracic pressures, at a small cost in arterial oxygenation. He/O(2) could offer an attractive option in COPD patients with PEEPi/dynamic hyperinflation.

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