Invasive Disease Due to Nontypeable Haemophilus Influenzae Among Children in Arkansas

Overview

Journal J Clin Microbiol

Specialty Microbiology

Date 2003 Jul 5

PMID 12843045

Citations 32

Authors

Joshua M ONeill

Joseph W St Geme 3rd

David Cutter

Elisabeth E Adderson

Juliana Anyanwu

Richard F Jacobs

Gordon E Schutze

Affiliations

Soon will be listed here.

Abstract

In this study, we reviewed cases of invasive disease due to nontypeable Haemophilus influenzae among children hospitalized at Arkansas Children's Hospital from 1993 to 2001. A total of 28 cases were examined, including 21 associated with bacteremia and 4 associated with meningitis. Of the patients examined, 86% were </=4 years of age, and 68% had underlying medical conditions. Characterization of the bacterial isolates by multilocus sequence type genotyping revealed significant overall genetic diversity, similar to the diversity in the general population structure for nontypeable H. influenzae. However, four separate pairs of isolates were closely related genetically, a relationship confirmed by pulsed-field gel electrophoresis and Southern hybridization studies using probes for the major H. influenzae adhesin genes. These results suggest that selected strains of nontypeable H. influenzae may have more invasive potential, especially in young children and patients with underlying medical conditions. At this point, the specific factors that contribute to enhanced virulence remain unclear.

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